乙型肝炎肝硬化患者血清透明质酸与HBV-DNA的相关性研究

目的探讨乙肝肝硬化患者血清透明质酸与HBV-DNA水平的相关性。方法收集144例乙肝肝硬化患者，其中女性42例，男性102例，年龄（54．42±11．53）岁，Childpugh A级42例，ChildpughB级40例，Childpugh C级62例，采用放射免疫法检测血清透明质酸，荧光定量PCR检测血清HBV-DNA水平，对血清透明质酸、血清HBV-DNA水平进行统计并分析二者之间的关系。结果①随着乙肝肝硬化Child分级的加重，患者的血清透明质酸水平也增高，不同分级之间的差异有统计学意义（P〈0．01）。②不同Childpugh分级患者的血清HBV-DNA水平无显著的统计学意义（P〉O．05）。③不同Childpugh分级患者的血清HBV-DNA和透明质酸水平无显著相关性（P〉0．05）。结论随着患者的Childpugh分级升高，HA水平显著增高，说明HA是反映肝硬化程度的敏感指标；乙肝肝硬化患者HBV-DNA与肝硬化程度无显著相关性，血清透明质酸与HBV-DNA水平之间也无显著相关性，因此抗病毒和抗纤维化治疗对乙肝肝硬化患者同等重要。

Correlative research of serum hyaluronic acid and HBV DNA levels in hepatitis B cirrhosis patients

Objective To investigate the relationship between serum HA and HBV-DNA levels in hepatitis B cirrhosis patients. Methods The data of 144 patients diagnosed with hepatitis B cirrhosis was collected. The average age was （54.424±11.53） years and there were 42 fema/es and 102 males. The cases were divided into Child pugh A, B, C groups according to Child pugh ranking. Serum HA of the patients was determined by radioimmunity assay and serum HBV DNA was determined by fluorescent quantitative PCR. The relationship between serum HA levels and HBV-DNA levels was analyzed. Results Serum HA of hepatitis B cirrhosis patients increased significantly and increased with the Child grade ascending （P〈0.01）. But there was no significant difference between serum HBV-DNA levels of three groups （P〉0.05）. Serum HA levels had no significant correlation with serum HBV-DNA levels （P〉0.05）. Conclusions HA is a promising marker of hepatic fibrosis in chronic hepatitis B. Serum HBV-DNA levels had no significant correlation with liver cirrhosis grades and serum HA levels had no significant correlation with serum HBV-DNA in hepatitis B cirrhosis patients. Anti-virus and anti-cirrhosis treatments are equally important for hepatitis B cirrhosis patients.