颈动脉粥样硬化斑块及颈动脉狭窄与脑梗死的相关性研究

背景颈动脉粥样硬化斑块及颈动脉狭窄与脑梗死的发生相关,应用彩色多普勒超声检测定量评估颈动脉粥样硬化的程度可否先期预测脑梗死的发生?目的探讨脑梗死患者颈动脉粥样硬化以及颈动脉狭窄与脑梗死的关系.设计以诊断为依据的病例对照研究.地点和对象研究对象为在佛山市第一人民医院住院的患者,均为佛山市常住居民,年龄23～87岁,其中脑梗死患者148例(脑梗死组),非缺血性心、脑血管疾病患者45例为对照组.方法对两组患者颈动脉进行彩色多普勒超声检查.主要观察指标观察两组患者颈总动脉内膜-中层厚度、斑块及狭窄情况.结果颈总动脉内膜-中层厚度增厚的发生率脑梗死组为76.6%,对照组为15.6%,脑梗死组高于对照组(x2=40.877,P＜0.001);颈动脉粥样硬化斑块的发生率脑梗死组为58.8%,对照组为26.7%,脑梗死组颈动脉粥样硬化斑块的发生率明显高于对照组(x2=12.99,P＜0.001),差异有显著性意义.结论颈动脉粥样硬化与脑梗死有关,同侧颈动脉粥样硬化斑块形成可能是引起脑梗死的原因之一.

Correlation between atheromatous plaque and stenosis of carotid and cerebral infarct

BACKGROUND: Carotid atheromatous plaque and stenosis correlate with the genesis of cerebral infarct. Does the quantitive evaluation of the carotid atheromatous severity by Colour Doppler Ultrasound predict the genesis of cerebral infarct?OBJECTIVE: To investigate the relationship between atheromatosis and stenosis of carotid and cerebra infarct.DESIGN: A case-controlled study based on diagnosis.SETTINGS and PARTICIPANTS: Patients selected from the Department of Inpatient of First People' s Hospital of Foshan were all usual residents of Foshan City aged from 23 to 87 years old, of which there were 148 cases of cerebra infarct(cerebral infarct group), and 45 cases of non-ischemic cardiac cerebrovascular diseases(control group).INTERVENTION: Colottr Doppler Ultrasound test was operated in all patients of two groups.MAIN OUTCOME MEASURES: The intima-medial-thickness(IMT),plaque and stenosis of common carotid artery were observed in both groups of patients.RFSULTS: The incidence of incrassated IMT of common carotid artery was 76.6% in the cerebral infarct group and 15.6% in the control group, which had statistical significant difference (x2 = 40. 877, P ＜ 0. 001) . The incidence of atheromatous plaque of common carotid artery was 58.8% in the cerebral infarct group and 26.7% in the control group, which had statistical significant difference(x2 = 12.99, P ＜ 0. 001).CONCLUSION: Carotid atheromatosis relates with cerebral infarct. The formation of homolateral carotid atheromatous plaque may be one of the reasons inducing cerebral infarct.