大叶山楝的化学成分研究

目的:对大叶山楝(Aphanamixis grandifolia)的枝叶部分进行化学成分研究。方法:对大叶山楝枝叶的95%乙醇提取物分别经石油醚和乙酸乙酯萃取。乙酸乙酯部分反复利用正相硅胶、反相RP-18、凝胶Sephadex LH-20等色谱方法进行分离纯化,并运用MS和NMR来鉴定化合物的结构。结果:从大叶山楝中分离鉴定了6个化合物,分别为:aromadendrane-4β,10β-diol(I),spathulenol(Ⅱ),eudesm-4(15)-ene-1β,6α-diol(Ⅲ),3α-cimnamoyloxykaur-16-en-19-oic acid(Ⅳ),phillygenin(V),3-methoxybenzoic-4-hydroxy acid(Ⅵ)。结论:6个化合物均为从该属植物中首次分离得到。

Studies on Chemical Constituents of the Leaves and Twigs of Aphanamixis grandifolia

Objective:To research the chemical constitutes isolated from the leaves and twigs of Aphanamixis grandifolia.Methods:The leaves and twigs of A.grandifolia were extracted with 95% ethanol,which was suspended in water and then extracted successively with petroleum ether and ethyl acetate.The ethyl acetate part was extensively separated over a series of chromatographic methods,including silica gel,RP-18,and Sephadex LH-20.These compounds were elucidated by extensive spectroscopic analysis(MS,NMR,and so on).Results: Six compounds,[aromadendrane-4β,10β-diol(I),spathulenol(Ⅱ),eudesm-4(15)-ene-1β,6α-diol(Ⅲ),3α-cimnamoyloxykaur-16-en-19-oicacid(Ⅳ),phillygenin(V),3-methoxybenzoic-4-hydroxy acid(Ⅵ).] were isolated and identified.Conclusion:Six compounds were all isolated from genus Aphanamixis for the first time.