难治性癫痫手术治疗效果及影响因素

目的探讨难治性癫痫手术治疗效果及影响因素分析。方法选取我院2004年1月至2011年6月进行手术治疗的难治性癫痫患者90例,随访1~3年后观察手术治疗效果,并对影响预后的相关因素进行分析。结果 90例患者预后满意30例,症状改善者40例,良好者10例,有10例较差,手术总有效率为88.9%。对影响因素进行单因素分析发现,病变部位、难治程度分型、手术治疗方式、病程和每日发作频率等有显著的相关性。排除各种复杂因素的影响,对单因素有统计学意义的因素进行多因素Logistic回归分析发现,病变部位、病程、手术治疗的方式和每日发作频率为影响难治性癫痫患者治疗的效果的独立危险因素(P0.05)。结论目前手术治疗难治性癫痫效果较好,但手术疗效受到多种因素的影响。

Analysis on surgical treatment effect and influencing factors of refractory epilepsy

Objective To study the surgical effect and influencing factors of refractory epilepsy. Methods From January 2004 to June 2011,90 patients with refractory epilepsy in our hospital were studied. All patients were treated by surgery and followed-up from 1 year to 3 years after treatment. The effect of surgery and the influence factors were analyzed. Results 30 cases of the 90 patients were satisfied with the prognosis, 40 cases improved symptoms, and there were 10 cases of good effect and 10 cases of poor effect. The total surgery effective rate was 88.9%. Univariate analysis showed there was a significant correlation with location of lesions, degree of refractory type, ways of surgical treatment, course of disease, and daily seizure frequency. Eliminate the influence of various complex factors, logistic regression a- nalysis showed that location of lesions, course of disease, ways of surgical treatment, and daily seizure frequency were independent risk fac- tors for the treatment of refractory epilepsy （ P 〈 0.05 ）. Conclusion Surgical treatment is good to refractory epilepsy, and the surgical cura- tive effect is influenced by many factors.