心肌血流储备分数在冠状动脉介入治疗术中的应用

目的：分析心肌血流储备分数（FFR）在冠状动脉介入治疗中处理临界病变策略制定的指导价值。方法：选择经冠状动脉造影（CAG）证实病变程度介于30％～70％的临界病变冠状动脉粥样硬化性心脏病患者24例，对靶血管行FFR检测，对FFR〈0．75的病变进一步行PCI治疗，FFR〉0．75的病变不予介入处理，所有患者均给予最优化药物治疗，3个月后随访患者心血管事件发生情况，进行心功能评价及复查血脂水平。结果：CAG提示46处临界病变，8例患者的11处病变行PCI治疗，治疗率为22％的，术后3个月总胆固醇水平较前明显降低，2例发生心绞痛事件，无1例发生心源性猝死或再次入院治疗。结论：在冠状动脉介入治疗中处理临界病变血管时，应用FFR测定辅助评估心肌供血，可以更合理的指导PCI。

The application of the myocardial fractional flow reserve in the coronary artery interventional therapy

Objective： To study the effect of fractional flow reserve （FFR） in the coronary artery interventional therapy in treating borderline lesions. Methods： Twenty-four subjects with borderline lesions of 30% - 70% degree certified by the coronary angiography （CAG） were included. FFR of the target vessel was measured by pressure wire, and patients with FFR 〈 0. 75 were further treated with PCI. All subjects were given the optimized drug therapy after the surgery. A 3-month follow-up was conducted to record the cardiac invents, cardiac function and the level of blood cholesterol. Results： There were 46 borderline lesions, and 11 of these in 8 subjects received PCI, the treatment rate of which was 22%. The 3-month follow-up showed that the total level of the cholesterol was significantly reduced. There were 2 cases of angina pectoris and no case of rehospitalization or cardiac death. Condusion： The application of myocardial FFR in the coronary artery interventional therapy in treating borderline lesions could be the reasonable guide for PCI.