组合型人工肾对维持性血透患者微炎症状态的影响

目的探讨组合型人工肾对维持性血透（maintenance hemodialysis,MHD）患者微炎症状态的影响。方法将42例MHD患者随机分为组合型人工肾组（HD＋HP）组和血液透析（HD）组,2组患者在首次治疗前后及,HD＋HP治疗8周后分别观察两组患者TNF-α、IL-6、CRP水平的变化。结果HD＋HP组治疗后,TNF-α、IL-6水平显著降低（P〈0.01）,CRP水平降低（P〈0.05）,治疗8周后复查比首次治疗后轻度降低,但无统计学意义（P〉0.05）;HD组治疗前后TNF-α、IL-6、CRP水平无统计学意义（P〉0.05）。结论组合型人工肾能有效降低MHD患者血清TNF-α、IL-6、CRP水平。通过本研究提示：进行间断的组合型人工肾治疗可以改善MHD患者微炎症状态。

The Effect of Hybrid Artificial Kidney on the Micro-inflammation State of Maintenance Hemodialysis Patients

Objective To discuss the effect of hybrid artificial kidney on the micro-inflammation state of MHD patients. Methods Divide 42 cases of MHD patients into group A（ HD ＋ HP） and group B （HD） radomly. Step 1 ： check the level of TNF-α, IL-1, IL-6, CRP of the two groups ; Step 2 ： conduct the treatment （ HP ＋ HD） on group A, sole hemodialysis on group B, and observe the change on the level of TNF-α,IL-1 ,IL-6,CRP before and after the first treatment and 8 weeks after the treatment. Results The level of TNF-α, IL-1, IL-6 of the patients who were treated with HP ＋ HD decreased significantly （ P 〈 O. 01 ）, the level of CRP was decreased slightly （ P 〉 0.05 ）. 8 weeks after the treatment the rechecked result decreased slightly;there was no statistically change on the level of TNF- α, IL-1, IL-6, CRP in group B （ P 〉 0.05 ）. Conclusion Hybrid artificial kidney can effectively decrease the level of TNF-α, IL-1, IL-6 in the serum of the MHD patients. This stduy showed that the micro-inflammation of state of MHD patients can be improved by the treatment of HP ＋ HD.