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| 血清软骨寡聚基质蛋白(COMP)检测在银屑病性关节炎患者中的意义研究 | |
| 引用本文： | 马英淳,陈志伟. 血清软骨寡聚基质蛋白(COMP)检测在银屑病性关节炎患者中的意义研究[J]. 医学信息, 2010, 0(2) |
| 作者姓名： | 马英淳 陈志伟 |
| 作者单位： | 苏州大学附属第一医院免疫风湿科; |
| 摘 要： | 目的:探讨银屑病性关节炎(PSA)患者血清软骨寡聚基质蛋白(COMP)水平变化及其对放射学改变的早期预测价值。方法:采用ELISA方法测定并对比分析22例银屑病性关节炎(PSA)与对照组及正常人血清中COMP的水平的差异,部分PSA患者各项临床指标及两年后关节放射学改良SHARP(vdH-Sharp)指数评分与COMP行相关性分析。结果:与仅有滑膜损害的其他关节炎患者及正常人群比较,PSA患者血清COMP显著升高(P<0.05)。PSA患者2年随访发现COMP与患者关节X线的改良SHARP评分前后差值呈正相关(P=0.01,r=0.754)COMP与初诊时的血沉(ESR)、C反应蛋白(CRP)、关节肿胀、压痛指数相关(P<0.05)。结论:COMP在PSA患者血清中异常增高,提示其可为PSA软骨病变早期诊断及判断软骨病变进展、预后和治疗效果的一项理想指标。 |
| 关 键 词： | 银屑病性关节炎 软骨寡聚基质蛋白 放射学 |
SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) LEVELS IN PSORIATIC ARTHRITIS(PSA) PATIENTS |
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| MA Ying-chun,CHEN zhi-wei. SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) LEVELS IN PSORIATIC ARTHRITIS(PSA) PATIENTS[J]. Medical Information, 2010, 0(2) | |
| Authors: | MA Ying-chun CHEN zhi-wei |
| Affiliation: | MA Ying-chun,CHEN zhi-wei. Department of rheumatology,The First Affiliated Hospital of Soochow University,Jiangshu 215000 |
| Abstract: | Objective:To explore whether serum cartilage oligomeric matrix protein (comp) levels were elevate or provided prognostic information on joint destruction in psoriatic arthritis (PSA). Methods:Serum levels of COMP were measured with ELISA and analysed in 22 different arthritic patients. The result of serum COMP were compared with clinical parameters and the delta joint modified Sharp scores after 2 years in a few PSA patients. Results:Serum COMP levels of PSA patients were higher than those in normal persons... |
| Keywords: | Psoriatic arthritis Cartilage oligomeric matrix protein (comp) Radiology |
| 本文献已被 CNKI 等数据库收录！ | |