慢性阻塞性肺疾病患者血清维生素D与炎症因子和肺功能相关性研究

目的探讨慢性阻塞性肺疾病(COPD)患者血清维生素D与炎性反应和肺功能的相关性。方法于2014年5月至2015年4月,选择急性加重期COPD患者60例,稳定期COPD患者50例,体检健康者40例,分析受试对象年龄、身高、体质量、吸烟情况等一般资料,采用Medisoft肺功能仪测量1秒用力呼气容积(FEV1)、用力肺活量(FVC)及呼气峰流速(PEF)。酶联免疫吸附试验检测血清25-羟基维生素D3[25(OH)D3]、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)。分析各指标的组间差异及各指标间的相关性。结果急性加重期和稳定期患者25(OH)D3水平低于健康者,IL-6、TNF-α水平高于健康者(P0.05)。急性加重期患者25(OH)D3水平低于稳定期患者,IL-6、TNF-α水平高于稳定期患者(P0.05)。急性加重期和稳定期COPD患者血清25(OH)D3水平与IL-6、TNF-α呈负相关(P0.05),与FEV1、PEF呈正相关(P0.05)。结论 COPD患者体内存在明显的维生素D缺乏或不足,且与炎性反应和肺功能具有一定的相关性。

Correlations of serum vitamin D with lung function and inflammatory factors in COPD patients

Objective To discuss the relationships between serum vitamin D and inflammatory response and lung function in chronic obstructive pulmonary disease(COPD) patients .Methods From May 2014 to April 2015 ,a total of 60 patients with acute exacerbation COPD(AE COPD) ,50 patients with stable period COPD (SP COPD) and 40 healthy subjects were enrolled .Data of age ,height ,weight ,smoking status and other general information were collected .Medisoft analyzer was used to detect forced expira‐tory volume in one second(FEV1) ,forced vital capacity (FVC) and peak expiratory flow (PEF) .Enzyme linked immunosorbent as‐say was performed to detect serum levels of 25‐dihydroxyvitamin D3[25(OH)D3] ,interleukin‐6(IL‐6) and tumor necrosis factor‐α(TNF‐α) .Differences and correlation between indicators ,mentioned above ,were analyzed .Results Serum levels of 25(OH)D3 in COPD patients were lower ,and those of IL‐6 and TNF‐αwere higher than healthy subjects(P<0 .05) .The levels of 25(OH)D3 in AE COPD patients were lower ,and those of IL‐6 and TNF‐αwere higher than SP COPD patients(P<0 .05) .In COPD patients ,ser‐um 25(OH)D3 level was significantly negatively correlated with IL‐6 and TNF‐α(P<0 .05) ,and positively correlated with FEV1 and PEF(P<0 .05) .Conclusion Serum vitamin D levels in patients with COPD could be obvious lack or deficient ,and might be correlated with inflammatory response and lung function .