2型糖尿病合并下肢血管病变患者网膜素-1与炎性因子检测的意义

目的探讨网膜素-1(omentin-1)与炎性因子与2型糖尿病(T2DM)患者下肢血管病变(LVD)的相关性。方法将126例T2DM患者分为T2DM组(68例)与T2DM+LVD组(58例),选择健康体检者40例纳入对照组,比较各组体质量指数(BMI)、腰臀比(WHR)、血压、空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、血脂、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、omentin-1、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和超敏C反应蛋白(hs-CRP),分析血浆omentin-1水平与其他指标的相关性,分析omentin-1的影响因素和T2DM患者发生LVD的影响因素。结果 T2DM组与T2DM+LVD组BMI、WHR、DBP、2FBG hPG、HbA1c、TC、TG、LDL-C、FINS、HOMA-IR、TNF-α、IL-6、hs-CRP均高于对照组,T2DM+LVD组病程长于T2DM组,对照组、T2DM组和T2DM+LVD组DBP、HbA1c、LDL-C、TNF-α、IL-6、hs-CRP呈升高趋势,omentin-1、ABI呈降低趋势,差异均有统计学意义(P0.05);omentin-1与ABI呈正相关(P0.05),与FPG、HbA1c、LDL-C、TNF-α、IL-6、hs-CRP均呈负相关(P0.05);TNF-α、ABI、HbA1c是血浆omentin-1水平的独立影响因素;omentin-1、TNF-α、IL-6和HbA1c是T2DM患者发生LVD的影响因素。结论 omentin-1可能参与了T2DM患者LVD的发生和发展,其血浆水平不仅受到糖脂代谢的影响,还可能受到炎性因子的影响。

Significance of detection of omentin-1 and inflammatory factors in type 2 diabetes mellitus patients with low limb vascular disease

Objective To investigate the correlation between omentin-1 and inflammatory cytokines in type 2 diabetes mellitus (T2DM )patients with low limb vascular disease(LVD) .Methods A total of 126 patients with T2DM were divided into T2DM group(68 patients) and T2DM + LVD group (58 patients) ,40 healthy controls were chosen as control group ,body mass index (BMI) ,waist-to-hip ratio(WHR) ,blood pressure ,fasting blood glucose(FBG) ,postprandial 2 hours blood glucose(2 hPG) ,glycat-ed hemoglobin(HbA1C) ,blood lipid ,fasting insulin(FINS) ,insulin resistance index(HOMA-IR) ,tumor necrosis factor-α(TNF-α) , omentin-1 ,interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)were compared between the two groups ,the correla-tion between plasma levels of omentin-1and other indicators was analysed ,the influence factors of omentin-1 and the influence fac-tors of LVD in patients with T2DM was analysed .Results BMI ,WHR ,DBP ,FBG ,2 hPG ,HbA1c ,TC ,TG ,LDL-C ,FINS ,HO-MA-IR ,TNF-α ,IL-6 ,hs-CRP of the T2DM group and the T2DM + LVD group were higher than those of the control group ,DBP , HbA1C ,LDL-C ,TNF-α ,IL-6 ,hs-CRP of the control group ,the T2DM group and the T2DM + LVD group showed a trend of in-creasing ,omentin-1 ,ABI showed a trend of decreasing ,the difference was statistical significant(P< 0 .05) .Omentin-1 was positively correlated with ABI(P < 0 .05) ,and negatively correlated with FBG ,HbA1C ,LDL-C ,TNF-α ,IL-6 ,hs-CRP (P < 0 .05) .TNF-α , ABI ,HbA1c were independent factors affecting the levels of plasma omentin-1 .omentin-1 ,TNF-α ,IL-6 and HbA1c were the influ-ence factors of occurrence of LVD in patients with T2DM .Conclusion Omentin-1 might participate in the occurrence and develop-ment of LVD in patients with T2DM ,plasma level of omentin-1 could be affected by glucose and lipid metabolism and inflammatory factors .