染色体异常及多态变异与不良生育患者染色体核型的相关性研究

目的对有不良生育史患者进行染色体核型分析,探讨染色体异常与多态变异与不良生育的关系,为优生优育进行指导。方法选取2012年至2015年来该院咨询有不良生育患者1 465对,进行外周血培养,细胞收获,制片以及G显带,并进行核型分析。结果 1 465对夫妇中染色体异常检出率为5.19%,其中男性1.84%,女性3.34%,男女差异有统计学意义(P0.05)。在具有不良生育史的患者中,早期流产患者的染色体异常检出率最高(8.05%),其次是有缺陷儿出生史的患者(8.00%),明显高于其他不良生育情况,差异有统计学意义(P0.05)。在具有不良生育史的患者中,染色体多态性总检出率为11.74%,男性检出率为10.85%,女性为0.89%,差异具有统计学意义(P0.05),其中死胎检出率(14.52%)以及早产检出率(12.68%)高于其他不良生育情况,差异具有统计学意义(P0.05)。结论染色体异常及多态变异可以导致不良生育的发生,所以染色体核型分析应作为优生优育的常规检查项目,为更好的优生优育进行指导。

Correlation of chromosomal abnormalities,chromosome polymorphism and chromosome karyotype in patients with abnormal fertility

Objective To explore the relationship between chromosomal abnormalities ,chromosome polymorphism and chromo‐some karyotype in patients with abnormal fertility and to direct aristogenesis and good brood .Methods A total of 1 465 couples with abnormal fertility who admitted in the hospital during 2013 to 2015 were given the peripheral blood culture ,cell harvest ,pro‐ducer and G banding and karyotype analysis .Results Detection rate of chromosome abnormality in 1 465 couples was 5 .19% , which of male (1 .84% ) was lower than that of female (3 .34% ) ,and the difference was statistically significant (P<0 .05) .In the patients with abnormal fertility ,the detection rate of chromosome abnormality in individuals with early abortion was the highest (11 .74% ) ,followed by the ones with birth defects (8 .00% ) ,which were higher than the other situations ,the differences was sta‐tistically significant ( P < 0 .05 ) .Meanwhile ,the detection rate of chromosome polymorphism was 11 .74% ,which of male (10 .85% ) was higher than that of female (0 .89% ) ,and the difference was statistically significant (P<0 .05) .The detection rate of stillbirth (14 .52% ) and premature birth (12 .68% ) were higher than other situations ,and the differences was statistically signifi‐cant (P<0 .05) .Conclusion Chromosomal abnormalities and chromosome polymorphism could lead to the occurrence of abnormal fertili‐ty .So the chromosome karyotype analysis should be treated as a routine inspection of optimal fertility project to direct good birth .