| HPLC指纹图谱的中成药质量控制模式研究 |
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| 引用本文： | 曾令杰,陈矛,王德勤,杨东升. HPLC指纹图谱的中成药质量控制模式研究[J]. 中成药, 2003, 25(5): 347-348 |
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| 作者姓名： | 曾令杰 陈矛 王德勤 杨东升 |
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| 作者单位： | 广州白云山制药股份有限公司白云山中药厂,广东,广州,510515 |
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| 摘 要： | 目的：探讨指纹图谱的质量控制模式。方法：采用HPLC法建立标准指纹图谱和样品指纹图谱，运用数值分类学和统计学原理，通过计算机求出样品图谱与标准品图谱之间的角余弦系数和距离系数来判别它们的相似性程度。结果：角余弦系数和距离系数相结合能够准确的判断样品和标准的相似程度。结论：该模式能有效的实施生产上的在线控制，保证不同批次产品质量的稳定一致。
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| 关 键 词： | HPLC 指纹图谱 质量控制模式 中成药 |
| 文章编号： | 1001-1528(2003)05-0347-02 |
| 修稿时间： | 2002-09-08 |
Study on HPLC fingerprint quality control model for traditional Chinese medicine |
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| ZENG Ling-ji,CHEN Mao,WANG De-qing,YANG Dong-sheng. Study on HPLC fingerprint quality control model for traditional Chinese medicine[J]. Chinese Traditional Patent Medicine, 2003, 25(5): 347-348 |
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| Authors: | ZENG Ling-ji CHEN Mao WANG De-qing YANG Dong-sheng |
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| Abstract: | Objective:To study an identifying model of HPLC fingerprint for the overall quality control of traditional Chinese medicine. Methods: A HPLC method is used to establish the standard fingerprint as well as sample fingerprint first. Then through the principles of numerical taxonomy and statistics, the similarity of the sample to the standard is tested by coefficients of cosine and distant, which are calculated with computer. Results: The combination of the two coefficients of cosine and distant can test the similarity of the sample to the standard correctly and accurately. Conclusion: The coefficients along with HPLC fingerprint can be applied to the on-line control in workshop to ensure the products' quality of all batches. |
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| Keywords: | HPLC fingerprint quality control model |
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