自体DC-CIK细胞联合化疗治疗晚期非小细胞肺癌的临床观察 |
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引用本文: | 王美清,彭大为,程小珍,何立香,谢宗宙,朱燕兴.自体DC-CIK细胞联合化疗治疗晚期非小细胞肺癌的临床观察[J].中国热带医学,2012,12(6):719-721. |
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作者姓名: | 王美清 彭大为 程小珍 何立香 谢宗宙 朱燕兴 |
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作者单位: | 海口市人民医院肿瘤科,海南海口,570208 |
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摘 要: | 目的 观察自体DC-CIK细胞联合化疗治疗晚期非小细胞肺癌的疗效.方法 62例确诊为肺癌的患者随机分为两组,A组31例(自体DC-CIK联合NP),B组31例(方案单用NP方案化疗),观察治疗前后的临床疗效及免疫学指标.结果 A组与B组比较,其有效率为(29.03% vs.19.35%),疾病控制率为(74.19%vs.51.60%)(P值分别为0.131、0.031),A组患者CD3+、CD4+细胞的百分比含量较治疗前明显提高,差异有统计学意义(P<0.05).结论 自体DC-CIK细胞联合化疗治疗晚期肺癌患者有控制肿瘤,改善生活质量及增强免疫功能的趋势.
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关 键 词: | 肺癌 细胞免疫 DC-CIK |
Effect of antilogous cytokine induced killer cells and dendrite cells combined with chemotherapy on advanced non-small cell lung cancer patients |
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Institution: | WANG Mei-qing,PENG Da-wei,CHENG Xiao-cheng,et al.(Tumor Department of Haikou Municipal Hospital,Haikou 570208,Hainan,P.R.China) |
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Abstract: | Objective To observe the clinical effects of autologous cytokine induced killer cells(CIK)and dendritic cells(DC)combined with chemotherapy on advanced non-small cell lung cancer(NSCLC)patients. Methods The 62 non-small lung cancere patients were randomly divided into group A comprised of 31 cases(DC-CIK+NP chemotherapy group)and group B comprised of 31 cases(NP chemotherapy group),by comparing the two groups of patients with lung cancer before and after treatment of clinical curative effect and T lymphocyte subtypes in peripheral blood. Results The effective rate in group A and group B were 29.03% and 19.35%,the response rate were 29.03%and 19.35%,and the disease control rate were 74.19% and.51.60%(P=0.131,P=0.031).The levels of CD3+and CD4+in the group A increasd after treatment,which showed significant statistical difference. Conclusion The use of autologus DC-CIK combined with chemotherapy for treatment advanced NSCLC has advantages of inhibiting the growth of tumor,enhancing immune function and improving the quality of life. |
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Keywords: | Lung cancer Cell immune DC-CIK |
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