| P38信号通路在肝脏缺血再灌注损伤中作用的研究进展 |
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| 引用本文： | 张海燕,黄汉飞,曾仲. P38信号通路在肝脏缺血再灌注损伤中作用的研究进展[J]. 昆明医学院学报, 2014, 0(2): 145-147,151 |
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| 作者姓名： | 张海燕 黄汉飞 曾仲 |
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| 作者单位： | 张海燕 (昆明医科大学第一附属医院器官移植中心,云南昆明,650032)； 黄汉飞 (昆明医科大学第一附属医院器官移植中心,云南昆明,650032)； 曾仲 (昆明医科大学第一附属医院器官移植中心,云南昆明,650032)； |
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| 基金项目： | 国家自然科学基金资助项目(项目编号：81360079) |
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| 摘 要： | 肝脏缺血再灌注损伤（hepatic ischemia reperfusion injury， HIRI）是临床上一种较为常见的病理生理现象，也是目前肝脏外科及肝移植临床研究的难点和热点问题，p38丝裂原活化蛋白激酶（mitogen activated protein kinase，MAPK）在多种疾病和应激条件下被大量激活，p38信号传导途径的激活是导致肝脏缺血再灌注损伤的重要机制之一，就近年来有关p38信号通路在肝脏缺血再灌注损伤中的作用及机制研究进行综述。
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| 关 键 词： | p38 肝脏 缺血再灌注损伤 |
The Research Progress of P38 Signaling Pathway in Liver Ischemia Reperfusion Injury |
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| ZHANG Hai-yan,HUANG Han-fei,ZENG Zhong. The Research Progress of P38 Signaling Pathway in Liver Ischemia Reperfusion Injury[J]. Journal of Kunming Medical College, 2014, 0(2): 145-147,151 |
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| Authors: | ZHANG Hai-yan HUANG Han-fei ZENG Zhong |
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| Affiliation: | (Organ Transplantation Center, The 1st Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650032, China) |
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| Abstract: | Hepatic ischemia-reperfusion injury,a relatively common phenomenon in clinical pathophysiology, is one of the currently difficult and hot issues in liver surgery and liver transplantation clinical studies. p38 mitogen activated protein kinases are activated in a variety of diseases and stress conditions. p38 signaling pathway activation is one of the important mechanisms leading to hepatic ischemia-reperfusion injury. This article reviews the roles and mechanisms of P38 signaling pathway recently years in the liver ischemia reperfusion injury. |
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| Keywords: | p38 liver ischemia reperfusion injury |
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