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| 高压氧对实验性脑出血大鼠的治疗作用 | |
| 引用本文： | 谢芹,尤春景. 高压氧对实验性脑出血大鼠的治疗作用[J]. 中国康复, 2004, 19(2): 75-77 |
| 作者姓名： | 谢芹 尤春景 |
| 作者单位： | 华中科技大学同济医学院附属同济医院康复医学科,湖北,武汉,430030 |
| 摘 要： | 目的 :观察高压氧 (HBO)对脑出血大鼠的治疗作用。方法 :实验大鼠随机分为正常组、对照组和HBO组 ,用尾状核胶原酶注射法制造大鼠脑出血模型。HBO组给予 5dHBO治疗。治疗后比较各组大鼠脑含水量、脑组织Na 、K 浓度及SOD和MDA含量 ,脑组织病理学变化。结果 :HBO组的脑含水量、Na 浓度低于对照组 (P <0 .0 1) ;K 浓度及SOD活性均高于对照组 (P <0 .0 1,P <0 .0 5 ) ,MDA含量低于对照组 (P <0 .0 5 ) ;病理检查见HBO组脑组织损害轻于对照组。结论 :HBO对脑出血大鼠有保护性治疗作用。 |
| 关 键 词： | 高压氧 脑出血 大鼠 模型 |
| 文章编号： | 1001-2001(2004)02-0075-03 |
Effect of Hyperbaric Oxygen on Cerebral Hemorrhage in Rats |
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| XIE Qin,YOU Chun-jing. Effect of Hyperbaric Oxygen on Cerebral Hemorrhage in Rats[J]. Chinese Journal of Rehabilitation, 2004, 19(2): 75-77 | |
| Authors: | XIE Qin YOU Chun-jing |
| Affiliation: | XIE Qin,YOU Chun-jing. Department of Rehabilitation Medicine,Tongji Hospital,Tongji Medical Collage,Huazhong University of Science and Technology,Wuhan 430030,China |
| Abstract: | Objective: To observe the effect of hyperbaric oxygen (HBO) on cerebral hemorrhage in rats. Methods: The rats were randomized into control group, cerebral hemorrhage group and cerebral hemorrhage with hyperbaric oxygen therapy group (HBO group). Collagenase was injected into caudate nucleus to establish a cerebral hemorrhage model in rat. HBO group was subjected to HBO treatment for 5 days (0.25 MPa, one h every day). The brain water content, Na , K in brain, superoxide dismutase (SOD) and malondialdehyde(MDA) in brain and pathological changes were observed after treatment. Results: In the HBO group brain water content and Na in brain were lower ( P <0.01) and K was higher ( P <0.01), the activity of SOD in brain tissue was higher ( P < 0.05) and MDA was lower ( P <0.05), pathological injury was milder than in cerebral hemorrhage group. Conclusion: HBO therapy has a protective effect on cerebral hemorrhage in rats. |
| Keywords: | hyperbaric oxygen cerebral hemorrhage rats model |
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