小剂量高渗盐水治疗兔失血性休克的实验研究

采用家兔（ｎ＝２４）复制失血性休克动物模型。治疗随机分为生理盐本组、高渗盐水组和回输失血组。观察休克前后及治疗后的多项指标变化。结果表明，采用小剂量高渗盐水（７．５％ＮａＣｌ，６ｍｌ／ｋｇ）能显著提高休克动物的平均动脉压，增加心搏量，减慢心率，增加尿量，改善微循环，降低呼吸频率和肺系数，提高生存率，与生理盐水组相比差异显著（Ｐ＜０．０５）。提示高渗盐水对失血性休克时多种官（心、肺、肾等）具保护作用，回输失血疗效相似，但前者的短期疗效略优于后者。

A STUDY OF THERAPEUTIC EFFECTS OF HYPERTONIC SODIUM CHLORIDE IN DOSAGE ON RABBITS WITH HEMORRHAGEIC SHOCK

rabbits with hemorrhageic shock were devided randomly into three groups for anti-shock treatment:normal saline group(NS group),hypertonic sodium chloride in small dosage(HS group) and infused shed blood group (IB group).The changes of some indexs were observed pre-and post-shock and during treatment. The results suggested that anti-shock treatment with HS could increase the mean arterial pressure(M AP),cardial output and urine volum;decrease heart rate(HR),respiratory frequency(R)and lung coeifficient; improve the mesenteric mierocireulation and increase the survial rate. As compared with normal saline,the difference was significant(P<0.05).The short-term therapeutic effect in HS group was somewhat superior to that in IB group.We concluded that anti-shock treatment with HS could prevent and cure cardial,lung and renal failure.