The effect of topical cyclosporin A on the rabbit cornea |
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| Authors: | W. Behrens-Baumann S. Theuring H. Brewitt |
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| Affiliation: | (1) Department of Ophthalmology, University of Göttingen, Federal Republic of Germany;(2) Department of Opthalmology, University of Hannover, Federal Republic of Germany;(3) Department of Ophthalmology, University of Göttingen, Robert-Koch-Str. 40, D-3400 Gö ttingen, Federal Republic of Germany |
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| Abstract: | ![]()
To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.Presented at the meeting of the Northwest German Society of Ophthalmology (Nordwestdeutsche Augenarzte), Hamburg, FRG, 2 June, 1985 |
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