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| 发酵液中R-扁桃酸的离子交换分离纯化 | |
| 引用本文： | 陈剑锋,史迎莹,陈浩,肖美添,毕鸣波,郭养浩. 发酵液中R-扁桃酸的离子交换分离纯化[J]. 药物生物技术, 2006, 13(2): 115-118 |
| 作者姓名： | 陈剑锋 史迎莹 陈浩 肖美添 毕鸣波 郭养浩 |
| 作者单位： | 1. 福州大学,药物生物技术与工程研究所,福建,福州,350002 2. 华侨大学化工系,福建,泉州,362011 |
| 基金项目： | 福建省自然科学基金;福建省科技厅科研项目;福建省计委资助项目 |
| 摘 要： | 研究发酵液中R-扁桃酸的离子交换分离工艺.采用711-OH型阴离子交换树脂从发酵液中分离R-扁桃酸时,最适动态吸附条件为上柱液pH值6.0～7.0、R-扁桃酸浓度70～80 mmol/L、苯乙酮酸浓度8～10 mmol/L和流速0.5 Bv/h,最适动态解吸条件为2% HCl为解吸液、解吸流速1.5 Bv/h.采用本工艺,发酵液中R-扁桃酸的总提取率为90.3%. |
| 关 键 词： | R-扁桃酸 发酵液 离子交换 711树脂 分离 |
| 文章编号： | 1005-8915（2006）02-0115-04 |
| 收稿时间： | 2005-07-13 |
| 修稿时间： | 2005-08-30 |
Separation and Purification of R-Mandelic Acid from Ferment Broth by Ion Exchange Technology |
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| CHEN Jian-feng,SHI Yin-ying,CHEN Hao,XIAO Mei-tian,BI Ming-bo,GUO Yang-hao. Separation and Purification of R-Mandelic Acid from Ferment Broth by Ion Exchange Technology[J]. Pharmaceutical Biotechnology, 2006, 13(2): 115-118 | |
| Authors: | CHEN Jian-feng SHI Yin-ying CHEN Hao XIAO Mei-tian BI Ming-bo GUO Yang-hao |
| Affiliation: | 1. Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University ,Fuzhou, 350002, Chinas2. Department of Chemical Engineering , Huaqiao University, Quanzhou, 362011, China |
| Abstract: | The purpose is to study a new method for the separation and purification of R-mandelic acid from ferment broth by ion exchange technology. While R mandelic acid separated from ferment broth at 711-OH anion exchange resin,the optimum dynamic adsorption condition was 6.0-7. 0 pH value, 70- 80 mmol/L R-mandelic acid concentration, 8 - 10 mmol/L phenylglyoxilic acid concentration and 0. 5 Bv/h velocity of flow. The optimum dynamic desorption condition was 2% HCl concentration and 0. ,5 Bv/h velocity of flow. 90.8% R-mandelic acid could be separated from ferment broth by this technicque. |
| Keywords: | R-mandelie acid Ferment broth Ion exchange 711 anion exchange resin Separation |
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