新生儿吸入性肺炎53例临床分析

目的: 观察新生儿吸入性肺炎临床表现,探讨酚妥拉明治疗新生儿吸入性肺炎疗效。方法: 将53例新生儿吸入性肺炎随机分成两组,治疗组32例,对照组21例。治疗组在常规氧疗、抗感染、支持治疗的同时加用酚妥拉明2~5 μg·kg-1·min-1,微泵输入,每天2次,每次2 h。观察两组呼吸困难消失及平均住院时间。结果: 治疗组总有效率93.7%,高于对照组61.9%(P<0.05)。呼吸困难消失时间和住院时间治疗组均短于对照组(P<0.001)。结论: 在常规治疗基础上加用小剂量酚妥拉明微泵滴注,能明显改善新生儿吸入性肺炎临床症状,缩短住院时间,临床应用安全、有效。

Clinical analysis of 53 newborns with aspiration pneumonia

Objective: To observe the clinical features of the newborns with aspiration pneumonia and to investigate the effect of phentolamine in treatment of the disease.Methods: Fifty-three newborns with aspiration pneumonia were randomly divided into phentolamine group(32 cases) and routine group(21 cases).In addition to the routine therapy of antibiotic,oxygen and support treatment,the test group were added phentolamine 2-5 μg·kg-1·min-1 twice a day,two hours at a time and the progress of the disease was observed.Results: The total effective rates were 93.7% and 61.9% in the phentolamine group and the routine group respectively.The difference between the two groups was remarkable(P<0.05);the time of ecphysesis and the hospital stay in the phentolamine group were significantly less than that of the routine group(P<0.001).Conclusions: The application of Phentolamine based on the routine treatment can obviously improve the clinical symptoms and shorten the hospital stay.It is safe and effective.