| DNA甲基化与胃癌的相关性 |
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| 引用本文： | 罗君,凌志强. DNA甲基化与胃癌的相关性[J]. 国际肿瘤学杂志, 2012, 39(2): 137-139. DOI: 10.3760/cma.j.issn.1673-422X.2012.02.018 |
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| 作者姓名： | 罗君 凌志强 |
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| 作者单位： | 1.浙江省肿瘤医院浙江省肿瘤研究所, 杭州,310022;2.浙江省肿瘤医院浙江省肿瘤研究所, 杭州,310022 |
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| 基金项目： | 浙江省科技计划资助项目 |
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| 摘 要： | 在胃癌的发展过程中常发现肿瘤相关基因的异常甲基化存在,其中包括全基因组的低甲基化和某些抑癌基因的高甲基化.另外,DNA甲基化水平似乎还与胃癌的预后密切相关.近年来为揭示DNA甲基化与胃癌的相关性进行了大量研究.
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| 关 键 词： | 胃肿瘤 DNA甲基化 基因表达 |
DNA methylation and gastric cancer |
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| LUO Jun , LING Zhi-qiang. DNA methylation and gastric cancer[J]. Journal of International Oncology, 2012, 39(2): 137-139. DOI: 10.3760/cma.j.issn.1673-422X.2012.02.018 |
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| Authors: | LUO Jun LING Zhi-qiang |
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| Abstract: | Abnormal methylation of the tumor-related genesis frequently found in the development of gastric cancer. Cancer cells exhibit two opposing methylation abnormalities: genome-wide hypomethylation and certain tumor suppressor gene hypermethylation. Furthermore, it seems that the level of DNA methylation is closely associated with the prognosis of gastric cancer. Recently, a great deal of research has been conducted to reveal thecorelation of DNA methylation and gastric cancer. |
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| Keywords: | Stomach neoplasms DNA methylation Gene expression |
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