| 肝细胞生长因子及其受体在多发性骨髓瘤中的研究进展 |
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| 引用本文： | 胡成琳,傅雷华,陈林. 肝细胞生长因子及其受体在多发性骨髓瘤中的研究进展[J]. 国际肿瘤学杂志, 2012, 39(5): 384-386. DOI: 10.3760/cma.j.issn.1673-422X.2012.05.018 |
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| 作者姓名： | 胡成琳 傅雷华 陈林 |
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| 作者单位： | 1.400010,重庆医科大学附属第二医院血液内科;2.400010,重庆医科大学附属第二医院血液内科;3.400010,重庆医科大学附属第二医院血液内科 |
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| 摘 要： | 肝细胞生长因子(HGF)是一个多功能的细胞因子,作用于细胞表面的跨膜受体c-Met发挥生物学作用.许多肿瘤的生长、侵袭和转移都与HGF-c-Met信号转导通路异常有关.HGF及其受体c-Met与多发性骨髓瘤(MM)的发生、转移、侵袭及预后关系密切.
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| 关 键 词： | 肝细胞生长因子 多发性骨髓瘤 |
Hepatocyte growth factor and its receptor in multiple myeloma |
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| HU Cheng-lin , FU Lei-hua , CHEN Lin. Hepatocyte growth factor and its receptor in multiple myeloma[J]. Journal of International Oncology, 2012, 39(5): 384-386. DOI: 10.3760/cma.j.issn.1673-422X.2012.05.018 |
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| Authors: | HU Cheng-lin FU Lei-hua CHEN Lin |
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| Affiliation: | Department of Hematology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China |
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| Abstract: | Hepatocyte growth factor （ HGF）, a muhifunctional cytokine, plays a biological role through acting on the cell surface transmembrane receptor c-Mct. The growth, invasion and metastasis of many tumors are associated with the abnormalities of HGF-c-Met signaling pathway. Studies found that HGF and its rcccptor c-Met have close relations with the occurrence, metastasis, invasion and prognosis of multiple myeloma. |
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| Keywords: | Hepatocyte growth factor Multiple myeloma |
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