核转录因子Sp1调控肿瘤血管生成研究进展

Sp1是人体内广泛表达的核转录因子之一,对维持机体正常发育及生理活动起重要作用,且在多种肿瘤组织中呈高表达.Sp1通过调控下游基因的转录表达,参与调节肿瘤的生长、侵袭及血管生成等多种生物学行为.某些生长因子及抑癌基因可通过Sp1调控血管内皮生长因子表达,参与肿瘤血管生成,其主要通过两种作用机制,即激酶诱导Sp1磷酸化及Sp1与其他蛋白的相互作用.

Progress of nuclear transcription factor Sp1 regulating angiogensis of tumor

Sp1 is one of the nuclear transcription factors which are widely expressed in human body. It plays an important role in human growth and physiological activities, and is highly expressed in many kinds of tumors’ tissue. Sp1 participates in regulating growth, invasion, angiogensis actions of tumor by regulating downstream gene’s transcription. Some grow factors and tumor suppressor genes can regulate the expression of VEGF by Sp1, and then participate in angiogensis of tumor by two main mechanisms: kinases inducing Sp1 phosphorylation and the interact of Sp1 and other proteins.