| 急性颅脑损伤患者脑脊液中髓鞘碱蛋白的变化及其意义 |
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| 引用本文： | 徐育林,杨新宇,杨树源,王明璐.急性颅脑损伤患者脑脊液中髓鞘碱蛋白的变化及其意义[J].华夏医学,1999(3). |
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| 作者姓名： | 徐育林 杨新宇 杨树源 王明璐 |
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| 作者单位： | 桂林市第二人民医院外二科，天津医科大学总医院神经外科 |
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| 摘 要： | 目的：为探讨急性颅脑损伤患者脑脊液（ＣＳＦ）中髓鞘碱蛋白（ＭＢＰ）的变化及意义。方法：用放射免疫分析法测定３４例急性颅脑损伤组患者ＣＳＦ中ＭＢＰ。结果：ＣＳＦ中ＭＢＰ在急性颅脑损伤组明显高于对照组（Ｐ＜０．０１），在ＡＤＣＩ患者明显高于ＡＬＣＩ患者（Ｐ＜０．０１）；ＡＤＣＩ患者入院时ＧＣＳ明显低于ＡＬＣＩ患者，而ＧＯＳ明显差于ＡＬＣＩ患者（Ｐ＜０．０１）；ＭＢＰ与ＧＣＳ和ＧＯＳ均呈明显负相关（ｒ＝－０．６１２，ｒ＝－０．５９８，Ｐ＜０．０１）。结论：急性颅脑损伤患者ＣＳＦ中ＭＢＰ升高，测定ＣＳＦ中ＭＢＰ有助于估计急性颅脑损伤患者病情轻重及预后；有助于ＡＤＣＩ的诊断。
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| 关 键 词： | 急性颅脑损伤 脑脊液 髓鞘碱蛋白 |
The Significance and Change of the Cerebrospinal Fluid Myelin Basic Protein for Acute Craniocerebral Injure |
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| Xu Yulin,Yang Xinyu,Yang Shuyuan,et al..The Significance and Change of the Cerebrospinal Fluid Myelin Basic Protein for Acute Craniocerebral Injure[J].Acta Medicinae Sinica,1999(3). |
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| Authors: | Xu Yulin Yang Xinyu Yang Shuyuan |
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| Institution: | Xu Yulin,Yang Xinyu,Yang Shuyuan,et al.//Department of surgery Guilin second hospital,Guilin Guangxi 541001 |
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| Abstract: | Objective:To study the change of Cerebrospinal fluid(CSF) Myelin Basic protein(MBP) for acute craniocerebral injure.Methods:MBP of 34 cases acute craniocerebral injure was determined by radioimmunity assay.Results:MBP of acute craniocerebral injure was clearly higher than those of control (P<0.01);MBP of acute diffuse craniocerebral injure (ADCI) was higher than those of acute local craniocerebral injure (ALCI) (P<0.01); Glasgow coma scale (GCS) of ADCI was lower than those of ALCI and GOS of ADCI was lower than those of ALCI (P<0.01);MBP of acute craniocerebral injure was negatively correlated with GCS and GOS (r=-0.612,r=-0.598,P<0.01). Conclusion:MBP of acute craniocerebral injure was higher than those of controls,it plays an important role in estimation and prognosis of acute craniocerebral injure by determining MBP,also in diagnosis of ADCI. |
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| Keywords: | acute craniocerebral injure Cerebrospinal fluid myelin basic protein |
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