加替沙星连续静脉滴注与序贯给药治疗泌尿生殖系统感染的成本-效果分析

目的评价加替沙星2种不同给药方案治疗泌尿生殖系统感染的成本-效果。方法将76例泌尿生殖系统感染患者随机分为A、B组,各38例,其中A组采用加替沙星注射液连续静脉滴注,B组采用加替沙星注射液/片序贯给药,并对2种方案进行成本-效果分析。结果2组在有效率、细菌清除率及不良反应发生率方面差异无显著性(P>0.05),但A组的治疗成本却明显高于B组(P<0.01),且成本-效果比A组高于B组。结论对泌尿生殖系统感染,采用序贯给药治疗不但安全、有效,而且更加经济、合理。

Treating Genitourinary Infections with Gatifloxacin by Continuous Intravenous Drip or Sequential Therapy: Cost - effectiveness Analyses

OBJECTIVE:To evaluate the cost-effectiveness of gatifloxacin for genitourinary infections by continuous intr_avenous drip or sequential therapy.METHODS:A total of 76 patients with genitourinary infections were randomized into 2 groups:38 cases in group A were assigned to receive gatifloxacin injection by continuous intravenous drip,another 38 cases in group B to receive gatifloxacin injection/tablet by sequential design.Cost-effectiveness analysis was performed on the 2 groups.RESULTS:No significant difference was noted between 2 groups in effective rates,bacterial clearance rates,and incidences of ADRs(P>0.05),but the treatment cost in group A was significantly higher than in group B(P<0.01),and the cost-effectiveness ratio in group A was also higher than in group B.CONCLUSION:The sequential therapy of gatifloxacin is safe,effective,economical and rational for genitourinary infections.