Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone) |
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| Authors: | E Perucca R Grimaldi G Ruberto C Gelmi F Trimarchi A Crema |
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| Institution: | (1) Institute of Medical Pharmacology, University of Pavia, Pavia, Italy;(2) Institute of Ophthalmology, University of Pavia, Pavia, Italy |
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| Abstract: | Summary The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone. |
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| Keywords: | phenobarbital propylhexedrine salt barbexaclone bioavailability pharmacokinetics healthy volunteers |
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