| 灯盏花注射液对脑缺血损伤的防治研究 |
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| 引用本文： | 陈康宁,董为伟. 灯盏花注射液对脑缺血损伤的防治研究[J]. 中国中西医结合杂志, 1998, 18(11): 684-686 |
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| 作者姓名： | 陈康宁 董为伟 |
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| 作者单位： | 重庆第三军医大学西南医院神经内科!重庆400038(陈康宁)，重庆医科大学神经病学研究所(董为伟) |
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| 基金项目： | 国家自然科学基金资助项目!(No.396 70 0 2 6 9) |
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| 摘 要： | 目的：研究灯盏花注射液对神经元缺血损伤的作用。方法：采用大脑全脑缺血／再灌流模型，观察了灯盏花注射液对蛋白激酶Ｃ活性，神经元内游离钙浓度及内皮层局部脑血流的影响。结果：发现灯盏花注射液可以防止脑缺血／再灌流诱发的蛋白激酶Ｃ的激活、钙超载及皮层局部血流的降低。结论：灯盏花注射液可以抑制蛋白激酶Ｃ的激活，防治神经元缺血性损伤。
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| 关 键 词： | 灯盏花注射液 脑缺血 再灌流 防治 |
Study on Effect of Erigeron Injection in Prevention and Treatment of Cerebral Ischemic Injury |
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| Chen Kangning. Study on Effect of Erigeron Injection in Prevention and Treatment of Cerebral Ischemic Injury[J]. Chinese journal of integrated traditional and Western medicine, 1998, 18(11): 684-686 |
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| Authors: | Chen Kangning |
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| Abstract: | Objective: To study the effect of Erigeron injection (EI) on cerebral ischemic injury. Methods: Animal model of brain ischemic/reperfusion was established in male Wistar rats and the effect of EI on proteinkinase C (PKC) activity, intraneuronal free calcium and regional cortex blood flow (rCBF) were observed. Results: EI could prevent the activation of PKC, calcium overload and decrease of RCBF induced by cerebral ischemia/reperfusion. Conclusion: EI could prevent neuronal ischemic injury by inhibiting activation of PKC. |
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| Keywords: | Erigeron injection cerebral ischemia proteinkinase C calcium overload regional cortex blood flow |
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