SUBACUTE HEPATIC FAILURE-A CLINICAL PROFILE |
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| Authors: | HS PRUTHI AC ANAND BALWINDER SINGH SP KALRA |
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| Affiliation: | *Associate Professor. Medicine and Gastroenterology, Armed Forces Medical College, Pune-40;+Reader. Department of Medicine, Armed Forces Medical College, Pune-40;#Classified Specialist, Medicine and Gastroenterology, Command Hospital (SC). Pune-40;**Consultant and Head. Armed Forces Medical College, Pune-40 |
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| Abstract: | ![]()
A combined experience of 37 cases of subacute hepatic failure encountered in five major gastroenterology centres over a period of ten years is discussed. Majority (65%) were males with average age of 38 years. Maximum (54%) were in 5th decade. Jaundice (100%), abdominal distention (38.7%), swelling feet (64%), fever (54%), abdominal pain (54%), exhaustion (78.3%) were the major presenting features. Jaundice and ascites were present in all cases. Pedal oedema (78.3%), hepatomegaly (54%), splenomegaly (32.4%) and encephalopathy (27%) were the other important clinical features. Hypoalbuminemia and prolonged prothrombin time were significant laboratory findings in addition to hyperbilirubinemia and elevated ALT and AST. Hbs Ag was detected in 46%. Major complications encountered were renal failure (48.7%), spontaneous bacterial peritonitis (43.2%), other infections (43.2%), encephalopathy (43.2%) and upper gastrointestinal bleed (22%). 54% died during stay in hospital. To conclude subacute hepatic failure is potentially fatal condition.KEY WORDS: Subacute hepatic failure, HBsAg, Jaundice |
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