Microbiome and pancreatic ductal adenocarcinoma |
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| Authors: | Annemilaï Tijeras-Raballand Marc Hilmi Lucile Astorgues-Xerri Rémy Nicolle Ivan Bièche Cindy Neuzillet |
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| Affiliation: | 1. OncoMEGA, Lamorlaye, France;2. Medical Oncology Department, Curie Institute, Versailles Saint-Quentin University (UVQ), Paris Saclay University, Saint-Cloud, France;3. Carte d’Identité des Tumeurs (Tumors Identity Card), La Ligue Contre le Cancer, Paris, France;4. Pharmacogenomic Unit, Genetic Department, Curie Institute, Paris, France;1. Diagnostic and Interventionnal Imaging Department – Antony Private Hospital, 1 Rue Velpeau, 92160 Antony, France;2. Surgery Department – Antony Private Hospital, 1 Rue Velpeau, 92160 Antony, France;1. Department of Medicine, Marienhausklinik St. Josef Kohlhof, Neunkirchen, Germany;2. Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany;1. Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA;2. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA;3. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA;4. Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA;1. Department of Surgery, Emory University, Atlanta, GA, USA;2. Department of Medicine, Emory University, Atlanta, GA, USA;3. Winship Cancer Institute, Emory University, Atlanta, GA, USA |
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| Abstract: | ![]()
Pancreatic ductal adenocarcinoma (PDAC) incidence and related-deaths are increasing worldwide. PDAC is characterized by poor prognosis due to late diagnosis, high metastatic capacity and resistance to therapy. This is partially due to its specific microenvironment, where the stroma is prominent over tumor cells. Besides the oral and gut microbiota, the intratumor microbiome, i.e. the bacterial and fungal microorganisms present within the tumor, was recently introduced as a new partner of the tumor microenvironment of PDAC modulating pancreatic carcinogenesis, intratumor immune infiltrates, and response to chemotherapy. In this review, we propose an overview of current knowledge about the roles of bacteria and fungi in PDAC development and biology, and discuss potential therapeutic implications. |
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| Keywords: | Dysbiosis Fungi Intratumor bacteria Microbiota Pancreatic cancer |
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