|
|||||
|
|
Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models |
|
| Authors: | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu rew CJ Huang First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital Shenzhen Guangdong Province China Second Clinical Medical College of Jinan University Shenzhen Institute of Geriatrics Shenzhen China School of Chinese Medicine Hong Kong Baptist University Kowloon Tong Hong Kong China Larry Hillblom Islet Research Center David Geffen School of Medicin... |
| Affiliation: | Yinghong Li1,Li Hu1,Zhengzhi Wu1,2,Zhiling Yu3,Meiqun Cao2,Kehuan Sun1,Yu Jin1,Anmin Wu1,Andrew CJ Huang4 1First Affiliated Hospital of Shenzhen University,Shenzhen Second People's Hospital,Shenzhen 518035,Guangdong Province,China 2Second Clinical Medical College of Jinan University,Shenzhen Institute of Geriatrics,Shenzhen 518020,China 3School of Chinese Medicine,Hong Kong Baptist University,Kowloon Tong,Hong Kong,China 4Larry Hillblom Islet Research Center,David Geffen School of Medicin... |
| Abstract: | This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expressio... |
| Keywords: | Alzheimer's disease endoplasmic reticulum stress Fructus Broussonetiae extract beta-amyloid peptide 25-35 D-galactose recognition neural regeneration |
| 本文献已被 CNKI 等数据库收录！ | |