脆性组氨酸三聚体蛋白在口腔鳞状细胞癌中的表达及意义

目的 探讨脆性组氨酸三聚体(FHIT)蛋白在口腔鳞状细胞癌组织中的表达及意义.方法 采用免疫组化法检测69例口腔鳞状细胞癌和40例正常口腔粘膜组织中FHIT的表达情况.资料的统计学处理用SPSS软件完成,比较用卡方检验.结果 口腔鳞状细胞癌组织中FHIT的阳性表达率(46.4%)低于正常口腔粘膜组织(77.5%),P＜0.05,有显著差异, FHIT的表达与年龄、性别无关(P＞0.05),而与分化程度相关,分化程度越低,FHIT的失表达越明显(P＜0.05).结论 FHIT的表达只与分化程度相关,随分化程度的降低,其失表达越明显.

Expression and significance of FHIT in oral squamous cell carcinoma

Objective To study the expression and significance of fragile histidine triad (FHIT) in oral squamous cell carcinoma (OSCC). Methods We adopted immunohistochemical methed in the study to investigate the expression of FHIT in 69 cases of OSCC and 40 normal oral mucosa. The data was analyzed by Chi-square test. Results Positive rate of FHIT in OSCC (46.4) was lower than that in normal oral mucosa (77.5). The difference was statistically significant (P<0.05). The expression of FHIT was not significantly correlated with age and sex of patients (P>0.05), but FHIT protein content was significantly associated with differentiation (P<0.05), the poorer the differentiation, the less the expression. Conclusion FHIT may play an important role in the occurrence and development of OSCC.