| 直接结晶苄青霉素钠的新方法 |
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| 引用本文： | 李十中,胡永平,王淀佐. 直接结晶苄青霉素钠的新方法[J]. 中国抗生素杂志, 2000, 25(3): 175-177,222 |
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| 作者姓名： | 李十中 胡永平 王淀佐 |
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| 作者单位： | 1. 北京科技大学,北京,100083
2. 中国工程院,北京,100038 |
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| 摘 要： | 经超滤处理后的青霉素发酵滤液，按现行工艺所得苄青霉素酸，可直接结晶苄霉素钠盐，改变了由钾盐转钠盐的间接法传统工艺，使钠盐收率提高６．７６％，其２８０ｎｍ吸光值小于０．０４，符合苄青霉素钠钠盐２８０ｎｍ吸光值小于０．０５的药典要求。
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| 关 键 词： | 苄青霉素钠 超滤 直接结晶 |
A new direct crystallization method of sodium penicillin G |
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| Li Shizhong,Hu Yongping,Wang Dianzuo. A new direct crystallization method of sodium penicillin G[J]. Chinese Journal of Antibiotics, 2000, 25(3): 175-177,222 |
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| Authors: | Li Shizhong Hu Yongping Wang Dianzuo |
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| Abstract: | A new method of direct crystallization of sodium penicillin G by Penicillium chrysogenum filtrate after ultrafiltration process. According to this method, we modified the traditional method with which sodium penicillin G is produced from potassium penicillin G, and increase the product yield 6.76%. The product obtained with the new method is conform to the pharmacopeia standard. |
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| Keywords: | Sodium penicillin G Ultrafiltration Direct crystallization |
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