肌钙蛋白I在不稳定性心绞痛患者中的临床意义

目的:观察不稳定性心绞痛患者(UAP)入院后血清肌钙蛋白I(cTnI)的变化,探讨UAP与心脏事件的近期、远期预测价值。方法:60例UAP患者分别在入院、入院后12h、24h、48h、10d各采血一次。用免疫发光法(IM-MULITE系统)测定cTnI浓度,分析其与心脏事件的关系。结果:在近期(30d)内,cTnI≥0.4ng/ml组与cTnI<0.4ng/ml组心脏事件发生率分别为48.15%和9.1%(P<0.05)。cTnI对近期发生心脏事件的阳性预测值48.15%,阴性预测值90.90%。远期:cTnI≥0.4ng/ml组病死率为18.52%(5/27);cTnI<0.4ng/ml组病死率为3.03%(1/33);(P<0.05)。结论:cTnI定量测定对UAP患者进行危险度分层有重要预测价值。

The Clinical Significance of Troponin I in Patients with Unstable Angina

Objective To observe the changes of serum troponinⅠ(cTnI) in patients with unstable angina (UA) and evaluate the short-term and future predictive value for cardiac events.Methods Blood samples were obtained at admission,12,24,48 hours and 10 days later from 60 consecutive UA patient.Serum concentration of cTnI were measured by IMMULITE system automatically.The relations between the change of cTnI and cardiac events including AMI,sudden death and refractory angina were analyzed.Result The incidence of cardiac events with in 30 days was significantly higher in group with increased cTnI (≥0.4 ng/ml) than that with normal cTnI (<0.4 ng/ml),(48.15% vs9.1%,P<0.05),Within the 1 year follow-up,cardiac sudden death occurred in 5 patients (18.52%) of the cTnI≥0.4 ng/ml group,whereas only 1 (3.03%) of the cTnI<0.4 ng/ml group (P<0.05).Conclusion The present study suggests that serum cTnI level detected quantitatively show very important predictive value for chrdiac event in patients with unstable angina pectoris.