| 莫沙必利联合质子泵抑制剂治疗胃食管反流病的系统评价 |
| |
| 引用本文： | 马雪,陈路佳,刘立立,罗梦林,唐尧.莫沙必利联合质子泵抑制剂治疗胃食管反流病的系统评价[J].中国药业,2011,20(24):31-35. |
| |
| 作者姓名： | 马雪 陈路佳 刘立立 罗梦林 唐尧 |
| |
| 作者单位： | 四川大学华西医院药剂科,四川,成都,610041 |
| |
| 摘 要： | 目的系统评价莫沙必利联合4种常用质子泵抑制剂治疗胃食管反流病(gastroesophageal reflux disease,GERD)的疗效和安全性。方法采用Cochrane系统评价方法,检索Pubmed,Embase,Cochrane图书馆(2010年第2期),CNKI,VIP,CBM等数据库。检索从建库至2010年9月,莫沙必利联合质子泵抑制剂治疗胃食管反流病的随机对照试验(RCT),对符合纳入标准的临床研究进行质量评价和资料提取后,采用RevMan 5.0进行Meta分析。结果共纳入18个研究计1 314例患者,与对照组(质子泵抑制剂单用)相比,试验组(莫沙必利联合质子泵抑制剂)对胃食管症状应答更显著OR=0.30,95%CI(0.22,0.42),P<0.000 01],对内镜下炎症应答更显著OR=0.31,95%CI(0.19,0.52),P<0.000 1],不良反应发生数更多OR=4.47,95%CI(1.74,11.46),P=0.002],但均较轻微,可耐受。结论莫沙必利联合质子泵抑制剂治疗胃食管反流病相对单用质子泵抑制剂疗效更显著,而安全性则稍差,但发生的不良反应均较轻微且可耐受。
|
| 关 键 词： | 莫沙必利 胃食管反流病 随机对照试验 系统评价 Meta分析 |
Systematic Evaluation on Mosapride Combined with PPI for Treating Gastroesophageal Reflux Disease |
| |
| Ma Xue,Chen Lujia,Liu Lili,Luo Menglin,Tang Yao.Systematic Evaluation on Mosapride Combined with PPI for Treating Gastroesophageal Reflux Disease[J].China Pharmaceuticals,2011,20(24):31-35. |
| |
| Authors: | Ma Xue Chen Lujia Liu Lili Luo Menglin Tang Yao |
| |
| Institution: | Ma Xue,Chen Lujia,Liu Lili,Luo Menglin,Tang Yao(Department of Pharmacy,West China Hospital,Sichuan University,Chengdu,Sichuan,China 610041) |
| |
| Abstract: | Objective To evaluate the effectiveness and safety of mosapride combined with 4 kinds of commonly used proton pump inhibitors(PPI) for treating gastroesophageal reflux disease(GERD).Methods The Cochrane systematic review method was adopted to retrieve PubMed,EMbase,Cochrane Library(Issue 2,2010),CNKI,VIP,CBM databases(from their inception to September 2010)for randomized controlled trials(RCTs) of mosapride combined with PPI in treating GERD.After the quality evaluation and data extraction,the clinical stud... |
| |
| Keywords: | mosapride gastroesophageal reflux disease(GRED) randomized controlled trial systematic review meta-analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
