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| 紫草素滴丸制备工艺的研究 | |
| 引用本文： | 冀文斌,刘涛. 紫草素滴丸制备工艺的研究[J]. 中国医药导刊, 2011, 13(10): 1804-1805 |
| 作者姓名： | 冀文斌 刘涛 |
| 作者单位： | 1. 内蒙古医学院附属人民医院,呼和浩特,010050 2. 内蒙古医学院,呼和浩特,010010 |
| 摘 要： | 目的:考察紫草素滴丸的制备工艺,设计正交实验,确定最佳工艺条件。方法:以聚乙二醇4000为基质,二甲基硅油为冷却剂,滴制工艺为:滴制温度85℃,冷却液5～25℃梯度冷却,滴距5cm,滴速40滴/min。结果:该工艺制得的滴丸圆整度好,丸重差异小,崩解时限为21 min,符合药典规定。结论:该工艺适合紫草素滴丸的制备。 |
| 关 键 词： | 紫草素滴丸 制备 正交实验 |
Study on Preparation of Shikonin Dropping Pills |
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| Ji Wen-bin,Liu Tao. Study on Preparation of Shikonin Dropping Pills[J]. Chinese Journal of Medicinal Guide, 2011, 13(10): 1804-1805 | |
| Authors: | Ji Wen-bin Liu Tao |
| Affiliation: | 1 People’s Hospital of Inner Mongolia Medical College,Huhhot 010050,China;2 Inner Mongolian Medical College,Huhhot 010010,China) |
| Abstract: | Objective:To study the technological parameters of the new drug Shikonin Dropping Pills and to establish the best conditions,the preparation conditions were optimized by orthogonal design.Methods:PEG4000 was an optimal base and methyl-silicon oil was an optimal refrigerant.The preparation process was as follows:The dropping system temperature was 85℃,the condensate temperature was 5-25℃by gradient cooling,the dropping distance was 5 cm,and 40 drops/min.Results:The dropping pills made by this technology had good properties of shaping and small weight deviation.The disintegration time was 21 min,which conformed to the standard pharmacopoeia.Conclusions:This method is suitable for the preparation of Shikonin Dropping Pills. |
| Keywords: | Shikonin Dropping Pills Preparation Orthogonal design |
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