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| 尼群地平对离体大鼠门静脉的作用 | |
| 引用本文： | 蒋祖明,李定国,陆汉明,刘玉兰,刘海林. 尼群地平对离体大鼠门静脉的作用[J]. 上海医学, 1993, 0(12) |
| 作者姓名： | 蒋祖明 李定国 陆汉明 刘玉兰 刘海林 |
| 作者单位： | 上海第二医科大学附属新华医院内科，上海第二医科大学附属新华医院内科，上海第二医科大学附属新华医院内科，上海第二医科大学附属新华医院内科，上海第二医科大学附属新华医院内科 |
| 摘 要： | 研究了尼群地平、硝苯啶对由钾离子或去甲肾上腺素引起收缩的离体大鼠门静脉作用。二种药物均能使钾离子和去甲肾上腺素剂量——反应曲线呈非平行右移,并降低最大反应值。尼群地平的PD′_2值分别为10.1530和8.8745,硝苯啶的PD′_2值分别为7.1204和6.3462,显示尼群地平对门静脉的扩张作用强于硝苯啶。 |
| 关 键 词： | 尼群地平 硝苯啶 大鼠门静脉 钾离子 去甲肾上腺素 |
EFFECT OF NITRENDIPINE ON ISOLATED RAT PORTAL VEIN |
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| Jiang Zu-ming,et al. EFFECT OF NITRENDIPINE ON ISOLATED RAT PORTAL VEIN[J]. Shanghai Medical Journal, 1993, 0(12) | |
| Authors: | Jiang Zu-ming et al |
| Affiliation: | Jiang Zu-ming,et al Department of Internal Medicine,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200025 |
| Abstract: | The effects of nitrendipine (Nit) and nifedipfne (Nif) on potassium-or noradrenaline-induced contraction in the isolated strips of rat portal vein were studied. Both of antagonized the actions of potassium and noradrenaline in a non-competitive manner. The dose-response curves of potassium and noradrenaline were shiffed to right with peak value somewhat declined. The PD_2' values of Nit against potassium and noradrenaline were 10.1530 and 8.8745; those for Nif 7.1204 and 6.3462, respectively. These resuhs suggested that the effect of Nit was stronger than that of Nif on isolated rat portal vein. |
| Keywords: | Nitrendipine Nifedipine Rat portal vein Potassium Noradrenaline |
| 本文献已被 CNKI 等数据库收录！ | |