中医周期疗法在PCOS不孕症患者促排卵周期中的疗效观察

目的:观察中医周期疗法结合西药促排卵治疗对多囊卵巢综合征(PCOS)不孕症患者排卵率、妊娠率及肌注人绒毛膜促性腺激素日(HCG日)子宫内膜厚度、类型,未破裂卵泡黄素化综合征(LUFS),克罗米芬(CC)反应不良及卵巢过度刺激综合征(OHSS)发生率的影响。方法:选取PCOS不孕症患者58例,随机分为对照组(克罗米芬+补佳乐),治疗组(克罗米芬+补佳乐+中医周期疗法),各29例,治疗3个月经周期,比较两组排卵率、妊娠率及HCG日子宫内膜厚度、类型,LUFS,CC反应不良及OHSS发生率。结果:对照组、治疗组总周期排卵率分别为64.38%,80.28%,两组比较差异具有统计学意义(P0.05)。治疗组HCG日A型子宫内膜所占比例高于对照组,两组比较差异具有统计学意义(P0.05)。治疗组妊娠率高于对照组,但两组比较差异无统计学意义。两组LUFS,CC反应不良及OHSS发生率均低于对照组,两组比较差异无统计学意义。结论:中医周期疗法结合西药促排卵治疗,可提高PCOS患者的排卵率,改善子宫内膜容受性,增加妊娠率,并减少LUFS,CC不反应的发生率。

Clinical Observation on Treatment of Polycystic Ovarian Syndrome Caused Sterility by Using TCM Periodic Therapy During Ovulation Induction

Objective: The aim of this study was to observe the efficacy of combination of traditional Chinese medicine(TCM) periodic therapy and western medicine clomiphene and progynovain treating polycystic ovarian syndrome(PCOS) causing infertility. Method: In our study, 58 patients with PCOS causing sterility were randomly divided into the control group (n=29) and the treated group (n=29).The treated group received the combination therapy and the control group was treated by the same dosage of clomiphene and progynova. Both groups received continuous treatment for 3 menstrual cycles. During treatment the endometrial thickness and type, the ovulation rate,the pregnancy rate,luteinized unruptured follicle syndrome(LUFS) rate,adverse reaction to clomiphene citrate and ovarian hyperstimulation syndrome(OHSS) rate were observed. Result: The periodic ovulation rate in the treated group was 80.28%,while in the control group it was 64.38%,with significant difference between two groups (P<0.05).The percentage of A type endometrium in the treated group was higher than that in the control group, the difference was significant (P<0.05). The total pregnancy rate is higher than that in the control group, but with no significant difference. Comparison of the occurrence of LUFS, adverse reaction to clomiphene citrate and OHSS between the two groups showed no significant difference. Conclusion: The combination therapy of clomiphene,progynova and TCM periodic therapy has a better therapeutic effect in treating PCOS causing infertility than that which only uses western medicine clomiphene and progynova.