| 女性HPV感染280例病理分析 |
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| 引用本文： | 王越月,周智辉,刘芳,田亚宁,杜静,田向勇.女性HPV感染280例病理分析[J].陕西医学杂志,2011,40(2):202-203,206. |
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| 作者姓名： | 王越月 周智辉 刘芳 田亚宁 杜静 田向勇 |
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| 作者单位： | 陕西中医学院第二附属医院病理科,咸阳,712000 |
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| 摘 要： | 目的:探讨女性宫颈HPV感染的临床病理特点。方法:280例宫颈病变组织采用原位杂交技术进行HPV6、11、16、18亚型的检测分析。结果:HPV16/18在CIN、CIN及CIN3组中的表达差异有显著性,在CIN中的表达低于CIN和CIN(P<0.05),HPV16/18的阳性表达在鳞状细胞癌级、鳞状细胞癌级、鳞状细胞癌级中的差异无统计学意义(P>0.05)。HPV6/11感染随着CIN级别的升高而降低,HPV16/18随着CIN级别的升高而升高。结论:女性HPV阳性感染率较高,具有年轻化的趋势,随着病变程度的不同,感染率及感染亚型不同;HPV16/18在CIN中的感染率随CIN的级别升高而升高,但在宫颈癌中则明显下降。
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| 关 键 词： | 子宫颈疾病 人乳头瘤病毒 感染 |
Pathological analysis of Human papilloma virus infection in 280 female cases |
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| Institution: | Department of Pathology,The Second Affiliated Hospital of Shaanxi Traditional Chinese Mediccal College(Xianyang 712000)Wang Yueyue Zhou Zhihui Liu Fang et al |
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| Abstract: | Objective：To confirm the characteristics of women infection about HPV.Methods：Using in situ hybridization in tissue sections on the HPV6,11,16,18 detection.Results：HPV16/18 infection in CIN Ⅰ,CIN Ⅱ and CIN Ⅲ three groups were significant difference（P0.05）,the difference of HPV16/18 positive expression in squamous cell carcinoma of grade Ⅰ,scales cell carcinoma Ⅱ,Ⅲ grade squamous cell carcinoma was not statistically significant（P0.05）.The infection of HPV6/11 increased with the level of the CIN decreased,the infection of HPV16/18 increased as the CIN grade increased.Conclusion：The infection of HPV about the women in the region of is higher,with the trend of younger.As the severity of disease,infection rates increase accordingly.The infection of HPV16/18 increased as the CIN grade increased,however,it decreased significantly in cervical cancer. |
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| Keywords: | Uterine cervical diseases Human papilloma virus Infections |
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