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| p16基因在乳腺浸润性导管癌中甲基化的研究 | |
| 引用本文： | 范昭,叶静,龙霞,张信. p16基因在乳腺浸润性导管癌中甲基化的研究[J]. 实用癌症杂志, 2011, 26(1): 34-36 |
| 作者姓名： | 范昭 叶静 龙霞 张信 |
| 作者单位： | 1. 北京大学深圳医院急诊科,518036 2. 北京大学深圳医院中心实验室,518036 |
| 摘 要： | 目的探讨p16基因启动子的甲基化与乳腺浸润性导管癌发生的关系。方法采用甲基化特异性聚合酶链反应法（MSP）,对42份乳腺浸润性导管癌组织和24份乳腺非癌组织进行p16基因甲基化检测。结果 42例乳腺癌中,18例检测到p16基因甲基化,甲基化率为42.9%;24例乳腺非癌组织中检测到2例（均为乳腺纤维腺瘤）甲基化,甲基化率为8.3%。p16基因启动子的甲基化率乳腺癌组与非癌组比较有显著性差异（χ2=8.619,P〈0.05）。结论 p16基因甲基化对乳腺浸润性导管癌的临床诊断具有一定指导意义。 |
| 关 键 词： | 乳腺癌 浸润性 导管 p16基因 甲基化 |
Methylation of p16 Gene in the Invasive Ductal Bbreast Cancer |
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| FAN Zhao,YE Jing,LONG Xia,et al.. Methylation of p16 Gene in the Invasive Ductal Bbreast Cancer[J]. The Practical Journal of Cancer, 2011, 26(1): 34-36 | |
| Authors: | FAN Zhao YE Jing LONG Xia et al. |
| Affiliation: | FAN Zhao,YE Jing,LONG Xia,et al.Department of Emergency,Peking University Shenzhen Hospital,Shenzhen,518036 |
| Abstract: | Objective To research the relation between methylation of p16 gene in promoter region and the invasive ductal breast cancer.Methods Methylation of p16 gene in 42 cases invasive ductal breast cancer tissues and 24 cases non-breast cancer tissues was examined by methylation-specific polymerase chain reaction(MSP).Results The methylation of p16 gene was detected in 18 cases of 42 cases breast cancer tissues.The methylation rate was 42.9%.2 cases breast fibroadenoma in 24 cases non-breast cancer tissues had the... |
| Keywords: | Breast cancer Invasive Ductal p16 gene Methylation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |