复方玄驹制剂抗炎作用的实验研究

目的 :观察复方玄驹中药制剂的抗炎作用。方法 :采用大鼠实验性关节炎模型 ,观察复方玄驹中药制剂对大鼠佐剂性足肿胀的抑制和治疗作用以及对角叉菜胶致大鼠足跖肿胀和大鼠棉球肉芽肿的影响。结果 :复方玄驹中药制剂对各种致炎剂引起的水肿均具有明显的抑制作用。口服 0.2 ,0.4,0.8g·kg^-1的复方玄驹中药制剂对角叉菜胶致大鼠足跖肿胀以及棉球肉芽肿有显著的抑制作用 ,用药后 1h对角叉菜胶致大鼠足肿胀的抑制率均达 25%以上 ,6h的抑制率分别为 23.8% ,22.2% ,39.7%。复方玄驹中药制剂对大鼠佐剂性足肿胀具有显著的预防和治疗作用。结论 :复方玄驹中药制剂对动物炎症模型具有明显的抗炎作用。

Study on Antiinflammatory Effect of A Compound TCM Agent Containing Ant Extractive in Animal Models

Objective: To study the antiinflammatory effect of a compound TCM (Traditional Chinese Medicine) agent on animal models. The agent contains ant extractive and a blent of three herbal products, herba epimedii, fructus cnidii, and fructus lycii. Method: Three animal models to induce experimental inflammation in rats, including carrageenin-induced paw edema, cotton-ball granuloma and adjuvant induced arthritis, were chosen to study the antiinflammatory effect of the TCM agent. Result: The TCM agent showed a marked inhibitory effect on edema induced by all three types of inflammation in rats, the inhibitory rate of the TCM agent at the dose of 0.20, 0.40 and 0.80 g·kg^-1 in granuloma model bing over 25% at 1 hour post oral administration, and being 23.8%, 22.7%, 39.7% at 6 hour. In addition, the TCM agent also showed a significant preventive as well as therapeutic effect on adjuvant induced arthritis in rats, and improved the pathological changes of the animal joints with the induced arthritis. Conclusion: TCM agent has significant antiinflammatory effects on the three above mentioned animal models.