| 阿魏酸载脂质体壳聚糖缓释微球的制备及体外研究 |
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| 引用本文： | 张继芬,王琴,贾兰,张宇,徐晓玉.阿魏酸载脂质体壳聚糖缓释微球的制备及体外研究[J].中国中药杂志,2010,35(22):2972-2975. |
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| 作者姓名： | 张继芬 王琴 贾兰 张宇 徐晓玉 |
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| 作者单位： | 西南大学药学院,重庆,400716 |
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| 摘 要： | 目的:将脂质体与壳聚糖微球两种载体结合,研究一种新的载脂质体壳聚糖微球口服缓释给药系统。方法:以阿魏酸为模型药物,醋酸钙梯度法制备脂质体后与壳聚糖溶液混合,离子凝聚法制备微球,分别对脂质体和微球进行表征,研究其体外释放性质。结果:脂质体的平均包封率为(79.97±0.54)%,平均粒径为(187.6±11.9)nm,Zeta电位为-12.67±1.78,4 h释药80%。再制备成壳聚糖微球后,药物以无定型态包于脂质体中,再完整地分散于壳聚糖微球中,平均包封率为(57.89±1.72)%,平均粒径为(1.17±0.15)mm。12 h时,脂质体自微球中释放出80.97%,药物释放出32.33%,明显低于壳聚糖微球78.98%的药物释放率。结论:载脂质体壳聚糖微球具有良好的体外缓释性能。
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| 关 键 词： | 阿魏酸 脂质体 醋酸钙梯度法 壳聚糖 微球 缓释 |
| 收稿时间： | 2/5/2010 12:00:00 AM |
Preparation and in vitro drug release of ferulic acid loaded chitosan microspheres containing liposomes |
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| ZHANG Jifen,WANG Qin,JIA Lan,ZHANG Yu and XU Xiaoyu.Preparation and in vitro drug release of ferulic acid loaded chitosan microspheres containing liposomes[J].China Journal of Chinese Materia Medica,2010,35(22):2972-2975. |
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| Authors: | ZHANG Jifen WANG Qin JIA Lan ZHANG Yu and XU Xiaoyu |
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| Institution: | College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China |
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| Abstract: | |
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| Keywords: | ferulic acid liposomes calcium acetate gradient chitosan microspheres sustainede-relaese |
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