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| 女性散发性基底细胞型乳腺癌ERα启动子甲基化的研究 | |
| 引用本文： | 毛晓韵,房月,井明晰,范垂锋,魏晶,姚凡,刘崇,金锋. 女性散发性基底细胞型乳腺癌ERα启动子甲基化的研究[J]. 中华肿瘤防治杂志, 2012, 19(10): 738-742 |
| 作者姓名： | 毛晓韵 房月 井明晰 范垂锋 魏晶 姚凡 刘崇 金锋 |
| 作者单位： | 1. 中国医科大学附属第一医院普通外科教研室,肿瘤外科,乳腺外科,辽宁沈阳110001 2. 中国医科大学药学院药理学教研室,辽宁沈阳,110001 3. 中国医科大学基础医学院病理学教研室,辽宁沈阳,110001 |
| 摘 要： | 目的:探讨ERα甲基化与基底细胞型乳腺癌发生发展的相关性。方法:用甲基化PCR研究60例散发性基底型乳腺癌ERα启动子甲基化情况,并研究其与临床病因素之间的关系。结果:女性散发性基底细胞型乳腺癌组织中ERα基因启动子甲基化发生率为80.0%(48/60)。ERα基因启动子甲基化与淋巴结转移情况、肿瘤分期、p53蛋白、BRCA-1蛋白和BRCA-2蛋白表达情况有相关性,与患者年龄及绝经状态无关。结论:ERα基因启动子甲基化在基底细胞型乳腺癌发生发展中可能起重要作用。 |
| 关 键 词： | 乳腺肿瘤 受体,雌激素 甲基化 |
Estrogen receptor-alpha promoter methylation in sporadic basal-like breast cancer |
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| MAO Xiao-yun , FANG Yue , JING Ming-xi , FAN Chui-feng , WEI Jing , YAO Fan , LIU Chong , JIN Feng. Estrogen receptor-alpha promoter methylation in sporadic basal-like breast cancer[J]. Chinese Journal of Cancer Prevention and Treatment, 2012, 19(10): 738-742 | |
| Authors: | MAO Xiao-yun FANG Yue JING Ming-xi FAN Chui-feng WEI Jing YAO Fan LIU Chong JIN Feng |
| Affiliation: | 1.Department of General Surgery,Department of Surgery Oncology,Department of Breast Surgery,First Affiliated Hospital,China Medical University,Shenyang 110001,P.R.China 2.Department of Pharmcology,China Medical University,Shengyang 110001,P.R.China 3.Department of Pathology,College of Basic Medical Sciences,China Medical University,Shenyang 110001,P.R.China |
| Abstract: | OBJECTIVE: To discuss the promoter methylation of estrogen receptor-alpha in sporadic basal-like breast cancer.METHODS: The methylation of ERα promoter was investigated in genomic DNA of 60 sporadic basal-like breast cancer by methylation-specific polymerase chain reaction.The correlation between ERα methylation and clinicopathological features of basal-like breast cancer was analyzed.RESULTS: ERα methylation was observed in 48 of 60(80.0%) sporadic basal-like breast cancer.No correlation was found between the ERα methylation and age,menopausal status,while it was significantly associated with lymph node metastasis,tumor stage,nuclear p53 accumulation,BRCA-1 and BRCA-2 expression in sporadic basal-like breast cancer.CONCLUSION: ERα methylation maybe plays an important role in basal-like breast carcinogenesiss. |
| Keywords: | breast neoplasms receptor,estrogen methylation |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |