|
|||||
|
|
Fluctuating PEEP (F–PEEP) versus conventional PEEP in dogs with asymmetrical lung injury |
|
| Authors: | H Inaba MD J Sato H Uchida M Sakurada T Ohwada T Mizuguchi |
| Institution: | Department of Emergency, School of Medicine, Chiba University, Japan. |
| Abstract: | Fluctuating PEEP (F-PEEP) is a newly developed PEEP in which end-expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with unilateral lung injury induced by the introduction of hydrochloric acid, F-PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at periods of 6 min, and conventional PEEP (C-PEEP) with an optimized EEP of 1.0 kPa, were each applied for 30 min. F-PEEP produced a significantly greater improvement of PaO2 and intrapulmonary shunt (QS/QT) than C-PEEP, and at the low EEP phase, the greatest improvement accompanied by an increased dynamic compliance and a large cardiac output was obtained. These results suggest that F-PEEP provides a useful mode of artificial ventilation for the treatment of unilateral lung injury. |
| Keywords: | Cardiac output dynamic compliance experimental dogs fluctuating positive end–expiratory pressure (F–PEEP) intrapulmonary shunt partial pressure of oxygen positive end–expiratory pressure unilateral lung injury |