CD44s mRNA在胃癌组织中的表达及其临床意义

目的探讨CD44s mRNA在胃癌组织中的表达及其临床意义。方法采用核酸原位杂交技术检测66例胃癌（胃癌组）、25例浅表性胃炎（胃炎组）和25例胃上皮不典型增生（增生组）中CD44s mRNA的水平。结果胃炎组无阳性表达;增生组中阳性率为20％;在胃癌组中阳性率为62．12％,胃癌组低分化组织中阳性率明显高于高分化组织（P〈0．05）,有淋巴结转移组阳性率明显高于无淋巴结转移组（P〈0．05）。结论CD44s mRNA表达与胃癌组织分化程度和转移有相关性;CD44s mRNA基因水平可作为判断胃癌病情和预后的指标。

Expression of CD44s mRNA in gastric carcinoma and its clinical significance

Objective] To study the clinical significance of CD44s mRNA in gastric carcinoma (GO. Methods] The expressions of CD44s mRNA in 66 cases of GC> 25 cases of superficial gastritis and 25 cases of atypical hyperplasia were examined by in situ hybridization. Results] There was no expression of CD44s mRNA in the group of superficial gastritis) the positive rate was 20% (5/25) in the group of atypical hyperplasia and 62. 12% (41/66) in the group of GC.The positive rate in poor differentiation group was obviously higher than that in well differentiation group (P<0. 05), and positive lymph node metastasis group was higher than that in negative lymph node metastasis group obviously (P<0. 05). Conclusion] The expression of CD44s mRNA is related with the differentiation degree and lymph node metastasis, the activation of CD44s gene is related to strong invasion and poor prognosis of cancer cell.