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| 凋亡相关基因bak在原发性肝癌中的表达及临床意义 | |
| 引用本文： | 林明睎,杨映红,杨发端,林秀芳,郑宇辉,王平,李秀金,王小众. 凋亡相关基因bak在原发性肝癌中的表达及临床意义[J]. 福建医药杂志, 2002, 24(5): 10-11 |
| 作者姓名： | 林明睎 杨映红 杨发端 林秀芳 郑宇辉 王平 李秀金 王小众 |
| 作者单位： | 1. 福建医科大学附属协和医院病理科,福建医科大学消化道肿瘤研究所,350001 2. 福建省肝胆研究所,350001 3. 福建省消化道研究室,350001 |
| 基金项目： | 福建省教委课题，编号 JA0 0 2 04 |
| 摘 要： | 目的：探讨细胞凋亡相关蛋白bak在原发性肝癌（Hcc）中的表达及其临床意义，方法：采用免疫组化SP方法，检测22例Hcc、22例Hcc伴肝硬变、20例肝为和10例正常肝组织中bak蛋白的表达，结果：bak蛋白阳性率，Hcc为88．63％（39／44），肝硬变为95％（19／20）两者无显著差别（P＞0．05），正常肝组织40％（4／10），结果：bak蛋白于Hcc，肝硬变均呈高表达，它在肝细胞和肝癌凋亡调控中可能居重要作用。 |
| 关 键 词： | bak 肝癌 细胞凋亡 病理 |
Expression of proapoptosis gene bak and its clinical Significance in pri mary hepatic carcinoma |
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| Lin Minxi,Yang Yinhong,Y an g Faduan,et al.. Expression of proapoptosis gene bak and its clinical Significance in pri mary hepatic carcinoma[J]. Fujian Medical Journal, 2002, 24(5): 10-11 | |
| Authors: | Lin Minxi Yang Yinhong Y an g Faduan et al. |
| Affiliation: | Lin Minxi,Yang Yinhong,Y an g Faduan,et al.Department of Pathology,Union Hospital of FMU,Fuzhou 350001,Chin a |
| Abstract: | Objective To search t h e expression and clinical significance o f apoposis associated protein bak in pri mary hepatocellular carcinoma(HCC).M ethod The expression of bak proteins in 22 cases of HCC,22 cases of HCC asso cisted with cirrhotic liver.20 cases of cirrhotic liver tissues and 10 cases of normal tissues were detected by immunohi stochemical SP method.Result The postive rate of bak protein in HCC was 88 63%(39/44) while that cirrhotic liver tissues was 95%(19/20) with significant difference between them(P>0 05) but posi tive rate of genebak in normal liver tis sues was 40%(4/10).Conclusion The gene bak was highest expression in HC C and cirrhotic liver tissues,so,gene bak plays an important role in controlled a poptosis in the liver cells and HCC. |
| Keywords: | Hepatic carcinoma ba k Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |