Mycobacterium avium and Mycobacterium abscessus complex target distinct cystic fibrosis patient subpopulations |
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| Authors: | Emilie Catherinot Anne-Laure Roux Marie-Anne Vibet Gil Bellis Sophie Ravilly Lydie Lemonnier Evelyne Le Roux Claire Bernède-Bauduin Muriel Le Bourgeois Jean-Louis Herrmann Didier Guillemot Jean-Louis Gaillard |
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| Affiliation: | 1. EA3647, UFR de Médecine Paris Ile-de-France Ouest, Université de Versailles Saint Quentin en Yvelines (UVSQ), 5-7 boulevard d''Alembert, 78280 Guyancourt, France;2. Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (AP-HP), 104 boulevard Raymond Poincaré, 92380 Garches, France;3. Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, 9 Avenue Charles de Gaulle, 92104 Boulogne-Billancourt, France;4. Service de Pneumologie, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France;5. INSERM, U 657, CeRBEP, Institut Pasteur, 25-28 rue du Dr Roux, 75015 Paris, France;6. PhEMI, Institut Pasteur, 25-28 rue du Dr Roux, 75015 Paris, France;7. Institut National d''Etudes Démographiques, 133 Boulevard Davout, 75020 Paris, France;8. Association Vaincre La Mucoviscidose, 181 rue de Tolbiac, 75013 Paris, France;9. Service de Pneumologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, 149 rue de Sèvres, 75015 Paris, France;10. RISE, UFR des Sciences de la Santé Paris Ile-de-France Ouest, UVSQ, 5-7 boulevard d''Alembert, 78280 Guyancourt, France |
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| Abstract: | ![]()
BackgroundClinical observations suggest that Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex (MABSC) may affect cystic fibrosis (CF) patients with different characteristics and risk factors, but this has never been demonstrated within a single prospective cohort.MethodsWe studied 50 MABSC-positive and 23 MAC-positive patients from a French prevalence study of non‐tuberculous mycobacteria (NTM) in CF. Risk factors specifically associated with MABSC and MAC were analyzed by nested case–control studies, with two NTM-negative controls matched by age, sex and center for each case.ResultsMAC-positive patients were significantly older than MABSC-positive patients (mean [SD] age, 23.1 [10.2] vs 17.4 [8.3] years, p = 0.013), and were also older at CF diagnosis (mean [SD] age, 12.9 [16.1] vs 3.1 [7.7] years, p = 0.015); they tended to be less frequent of the ΔF508/ΔF508 genotype (33.3 vs 61.1%, p = 0.17) and to use pancreatic extracts less frequently (82.4 vs 97.6%, p = 0.07). Risk factors identified by multivariate analysis were: i) in the MAC case–control study, an older age at CF diagnosis (p = 0.004); ii) in the MABSC case–control study, at least one course of intravenous antibiotics (p = 0.01) and more frequent isolation of Aspergillus (p = 0.03).ConclusionsMAC affects adult patients with a mild form of CF, whereas MABSC affects younger patients with more severe CF and more frequent intravenous antimicrobial treatment. |
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