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Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells |
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| Authors: | Marta Forn Mar Muñoz Daniele V.F. Tauriello Anna Merlos-Suárez Verónica Rodilla Anna Bigas Eduard Batlle Mireia Jordà Miguel A. Peinado |
| Affiliation: | 1. Institute of Predictive and Personalized Medicine of Cancer (IMPPC), 08916 Badalona, Barcelona, Spain;2. Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain;3. Institut Hospital del Mar d''Investigació Mèdica (IMIM), 08003 Barcelona, Spain;4. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain |
| Abstract: | |
| Keywords: | Gene silencing DNA methylation Colorectal cancer Chromatin marks Histone modification Long range epigenetic silencing Cell differentiation LRES" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Long range epigenetic silencing ChIP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" Chromatin immunoprecipitation ISC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Intestinal stem cells |
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