Clinical Characteristics of Patients with Hepatitis C Virus-Related Chronic Liver Disease Seropositive for Anticentromere Antibody |
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| Authors: | Himoto Takashi Nakai Seiji Kinekawa Fumihiko Yoneyama Hirohito Deguchi Akihiro Kurokochi Kazutaka Masaki Tsutomu Senda Shoichi Haba Reiji Watanabe Seishiro Nishioka Mikio Kuriyama Shigeki |
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| Affiliation: | (1) Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan;(2) Department of Integrated Medicine, Kagawa University School of Medicine, 1750-1, Ikenobe, Miki-Cho, Kita-Gun, Kagawa 761-0793, Japan;(3) Department of Diagnosis Pathology, Kagawa University School of Medicine, Kagawa, Japan;(4) Department of Gastroenterology, Kagawa Prefectural Central Hospital, Kagawa, Japan |
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| Abstract: | The association between anticentromere antibody (ACA) and hepatitis C virus (HCV) infection remains unclear. We subjected eight patients with HCV-related chronic liver disease (CLD) seropositive for ACA to a battery of clinical and laboratory tests. The patient cohort was dominated by females, and four of the eight (50%) patients had a concomitant autoimmune disease. All of the patients had high titers of ACA (≥1:320). The histological activity index scores in chronic hepatitis C (CH-C) patients with ACA were significantly higher than those in CH-C patients without antinuclear antibody (ANA) (12.8 ± 1.8 vs. 8.3 ± 4.5, P = 0.0372). The frequency of human leukocyte antigen (HLA) DR-8 in patients with HCV-related CLD seropositive for ACA was significantly higher than that in patients with CH-C seronegative for ANA (71 vs. 18%, P = 0.0108). These findings suggest that ACA is induced by chronic HCV infection in association with HLA DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and inflammation than CH-C patients without ANA. |
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| Keywords: | Anticentromere antibody Autoimmune phenomena Chronic hepatitis Hepatitis C virus Human leukocyte antigen phenotype |
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