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Breast Cancer Genes
Authors:Anne M. Bowcock  Ph.D.
Affiliation:Department of Pediatrics, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Texas
Abstract:Abstract: The identification of familial breast cancer genes heralds an era of directed breast cancer treatment. Currently, two hereditary breast cancer genes have been identified, BRCA-1 and BRCA-2 . Although accounting for only approximately 5% of all breast cancers, they are being used to identify women with germ-line alterations that are at high risk of developing breast or ovarian cancer. With the identification of such genes comes a need for consideration of the ethical issues associated with testing. These genes are also being examined from a biochemical standpoint encompassing both their biological roles and biochemical pathways in which they reside. Such studies are likely to lead to novel breast cancer therapies.
Keywords:hereditary breast cancer genes    breast cancer    BRCA-1    BRCA-2    BARD-1    estrogen    genetic testing
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