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| 细胞因子对体外培养大鼠肾小球及肾小球系膜细胞分泌TNF的影响 | |
| 引用本文： | 于德民 何庆. 细胞因子对体外培养大鼠肾小球及肾小球系膜细胞分泌TNF的影响[J]. 天津医药, 1997, 25(7): 409-412 |
| 作者姓名： | 于德民 何庆 |
| 作者单位： | 天津医科大学总医院内分泌科，天津医科大学总医院内分泌科，天津医科大学总医院内分泌科，北京医科大学第一附属医院神经内科，天津医科大学总医院内分泌科 300052，300052，300052，300052 |
| 摘 要： | 采用ＥＬＩＳＡ法，观察了正常大鼠肾小球及ＧＭＣ在体外培养期间分泌ＴＮＦ的变化规律及不同细胞因子对其分泌ＴＮＦ的影响。结果表明：体外培养的肾小球与ＧＭＣ具有分泌ＴＮＦ的功能，而且不同的时相ＴＮＦ分泌的量不等。ＩＬ－１对其分泌ＴＮＦ无影响。ＩＬ－６抑制肾小球分泌ＴＮＦ，但促进ＧＭＣ分泌ＴＮＦ。ＥＴ－１能明显促进ＴＮＦ的分泌，而且促进的幅度与其浓度成正比。 |
| 关 键 词： | 细胞因子 肾小球 系膜细胞 TNF 糖尿病肾病 |
Effects of Cytokines on Secretion of TNF by Glomeruli and Glomerular Mesangial Cells in Vitro |
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| Yu Demin,He Qing,Xu Huan.et al. Effects of Cytokines on Secretion of TNF by Glomeruli and Glomerular Mesangial Cells in Vitro[J]. Tianjin Medical Journal, 1997, 25(7): 409-412 | |
| Authors: | Yu Demin He Qing Xu Huan.et al |
| Affiliation: | Yu Demin,He Qing,Xu Huan.et al Department of Endocrinology,Tianjin Medical University General Hospital 300052 |
| Abstract: | The secretion of tumor necrosis factor(TNF)by the normal rat glomeruli and glomerular mesangial cells(GMC)was studied in vitro,and the effects of interleukin-1(IL-1) >IL-6 and ET-1 at different concentrations on the secretion of TNF were observed. The results showed that normal glomeruli and GMC in vitro had the function of secreting TNF with variable quantity of TNF at different times. IL-1 had no effect on them, IL-6 inhibited the secretion of TNF by glomeruli but promoted the secretion by GMC- ET-1 promoted the secretion of TNF by glomeruli and GMC,and the effects were associated with the concentrations of ET-1. |
| Keywords: | glomeruli mesangial cell cytokines |
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