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原发性肝癌患者介入治疗前后SE-CAD,CA19-9和VEGF水平的变化
引用本文:杨华喜. 原发性肝癌患者介入治疗前后SE-CAD,CA19-9和VEGF水平的变化[J]. 标记免疫分析与临床, 2007, 14(1): 4-6
作者姓名:杨华喜
作者单位:怀化市第二人民医院检验科,湖南,怀化,418200
摘    要:为探讨原发性肝癌患者介入治疗前后,血清可溶性上皮钙粘蛋白(SE-CAD),糖类抗原19-9(CA19-9)和血管内皮生长因子(VEGF)水平的变化,本文应用RIA测定了32例患者血清CA19-9的水平,ELASA测定SE-CAD和VEGF水平,并与35名健康人相比较.患者介入治疗前后SE-CAD,CA19-9和VEGF水平明显高于正常组(P<0.01).介入治疗后30例中,有20例在6个月以后没有复发,患者血清三项指标回落至正常范围,介入治疗后6个月,10例复发患者血清SE-CAD,CA19-9和VEGF水平的变化与患者的病情和愈后密切相关,有一定的实用价值.

关 键 词:原发性肝癌  糖类抗原19-9  可溶性上皮钙粘蛋白  血管内皮生长因子
文章编号:1006-1703(2007)01-0004-03
修稿时间:2006-07-12

Changes of Serum SE-CAD, CA19-9 and VEGF Levels in Patients with Primary Hepatic Cancer Before and After Intervention Therapy
YANG Hua-xi. Changes of Serum SE-CAD, CA19-9 and VEGF Levels in Patients with Primary Hepatic Cancer Before and After Intervention Therapy[J]. Labeled Immunoassays and Clinical Medicine, 2007, 14(1): 4-6
Authors:YANG Hua-xi
Abstract:To explore the changes of serum SE-CAD,CA19-9 and VEGF levels in patients with primary hepatic cancer before and after intervention therapy,serum CA19-9 levels were detected by RIA,and serum SE-CAD and VEGF levels by ELISA in 32 patients and 35 healthy controls.The results showed that serum SE-CAD,CA19-9 and VEGF levels in patients before intervention therapy were significantly higher than those in control group(P<0.01).Twenty of 30 patients after 6 months of intervention therapy showed no sign of recurrence of cancer,and their serum SE-CAD,CA19-9 and VEGF levels dropped to normal range. The changes of serum SE-CAD,CA19-9 and VEGF levels in other 10 patients with recurrence of cancer were closely related to the disease process of primary hepatic cancer and might be regarded as useful values.
Keywords:Primary hepatic cancer   Carbohydrate antigen19-9   Soluble epieyte cadherin  Vascular endothelian growth factor
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