| 中国南海海绵Aaptos suberitoides的化学成分 |
| |
| 引用本文： | 贺倩倩,苗双,黄莹洁,李敏,满玉清,宫凯凯.中国南海海绵Aaptos suberitoides的化学成分[J].滨州医学院学报,2021,44(1):61-64. |
| |
| 作者姓名： | 贺倩倩 苗双 黄莹洁 李敏 满玉清 宫凯凯 |
| |
| 作者单位： | 1 滨州医学院药学院 山东 烟台 264003;2 滨州医学院附属医院肿瘤研究实验室 山东 滨州 256603;3 滨州医学院附属医院药学部 山东 滨州 256603;4 滨州医学院附属医院疼痛科 山东 滨州 256603 |
| |
| 基金项目： | 滨州医学院科研计划;滨州市科技发展计划;山东省自然科学基金;国家自然科学基金;滨州医学院科研启动基金;山东省中医药科技发展计划 |
| |
| 摘 要： | 目的 研究中国南海海绵Aaptos suberitoides中化学成分。方法 运用薄层色谱、Sephadex LH-20凝胶色谱、硅胶色谱、半制备高效液相各种色谱手段对化合物进行分离纯化。利用核磁共振、质谱等波谱学手段,并结合其他理化性质及文献数据鉴定化合物的结构。结果 从海绵Aaptos suberitoides的甲醇粗提取物中分离鉴定了7个单体化合物,分别为3-(methylamino)demethyl(oxy)aaptamnie、aaptamine、尿嘧啶、胸腺嘧啶、环(脯-丝)二肽cyclo(Pro-Ser)]、环(脯-苏)二肽cyclo(Pro-Thr)]、脱氧胸腺嘧啶核苷。结论 化合物aaptamine、环(脯-丝)二肽cyclo(Pro-Ser)]、环(脯-苏)二肽cyclo(Pro-Thr)]为首次从本属海绵中分离得到。
|
| 关 键 词： | 海绵 Aaptos suberitoides 化学成分 结构鉴定 |
| 收稿时间： | 2020-10-10 |
Study on the chemical constituents of sponge Aaptos suberitoides from the South China Sea |
| |
| HE Qianqian,MIAO Shuang,HUANG Yingjie,LI Min,MAN Yuqing,GONG Kaikai.Study on the chemical constituents of sponge Aaptos suberitoides from the South China Sea[J].Journal of Binzhou Medical College,2021,44(1):61-64. |
| |
| Authors: | HE Qianqian MIAO Shuang HUANG Yingjie LI Min MAN Yuqing GONG Kaikai |
| |
| Institution: | 1.School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, P.R.China;2.Cancer Research Institute, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China;3.Department of Pharmacy, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China;4.Department of Pain Medicine, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China |
| |
| Abstract: | Objective To investigate the chemical constituents of sponge Aaptos Suberitodes.Methods The compounds were isolated and purified by TLC, Sephadex LH-20 column, sillica gel column chromatography and semi-preparative HPLC. Their chemical structures were identified by NMR, MS and comparison with the data of literatures. Results From the CH3OH extract of Aaptos suberitoides, seven compounds were isolated and their structures were determined as 3-(methylamino)demethyl(oxy)aaptamnie, aaptamine, uracil, thymine, cyclo(Pro-Ser), cyclo(Pro-Thr) and thymine nuleoside.Conclusion Aaptamine, cyclo(Pro-Ser) and cyclo(Pro-Thr) were isolated from the genus Aaptos for the first time. |
| |
| Keywords: | sponge Aaptos suberitoides chemical constituents structure identification |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《滨州医学院学报》浏览原始摘要信息 |
| 点击此处可从《滨州医学院学报》下载免费的PDF全文 |
|
